Phenotypes associated with this allele

• Allele Symbol: Cdk5r1^tm1Ohsh
• Allele Name: targeted mutation 1, Toshio Ohshima
• Allele ID: MGI:2680652
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh	involves: 129 * C57BL/6J	MGI:3719575
hm2	Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh	Not Specified	MGI:3719564

Genotype
MGI:3719575

hm1

• Allelic Composition: Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:100692 )

• in a Morris maze test with hidden platform, spatial learning and memory are impaired

impaired coordination ( J:215344 )

♂ • at 3 months of age, males show a significantly impaired ability to maintain balance on a rotating rod at two different speeds (5 and 10 rpm)

♂ • however, grip strength is normal in a traction test, indicating that poor rotarod performance is not due to muscle weakness

nervous system

abnormal hippocampus granule cell morphology ( J:100692 )

• granule cells are dispersed in the dentate gyrus

abnormal hippocampus pyramidal cell morphology ( J:100692 )

• CA3 pyramidal neurons are disorganized

reduced long-term depression ( J:100692 )

• long term depression in response to low-frequency stimulation is only transiently decreased and returns to baseline within 10 to 15 minutes whereas depression is long-term in wild-type mice

• following stimulation with tetanus, depotentiation is impaired

Genotype
MGI:3719564

hm2

• Allelic Composition: Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh
• Genetic Background: Not Specified

behavior/neurological

increased thermal nociceptive threshold ( J:105661 )

• mice exhibit a 2-fold or greater increase in withdrawal latency time