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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plcb3tm1Dwu
targeted mutation 1, Dianqing Wu
MGI:2680661
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plcb3tm1Dwu/Plcb3tm1Dwu involves: CD-1 MGI:3715311
hm2
 		Plcb3tm1Dwu/Plcb3tm1Dwu Not Specified MGI:4358153
cx3
 		Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu 		involves: 129S1/Sv MGI:4358152
cx4
 		Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu 		involves: 129S1/Sv * CD-1 MGI:4358173


Genotype
MGI:3715311
hm1
Allelic
Composition		 Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
analgesia ( J:57478 )
• mutants are more sensitive to antinociceptive effects of morphine than wild-type mice
• mutants show a 5-fold increased sensitivity to morphine as measured by antinociception in hot plate tail-flick assay

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:66819 )
• in response to somatostatin, there is no influx of calcium measured in aortic smooth muscle cells in mutants compared to wild-type cells which show show an increased calcium level




Genotype
MGI:4358153
hm2
Allelic
Composition		 Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
spontaneous skin ulceration ( J:60348 )
• at 6 months or older behind the ears, on the next, or sometimes on the face




Genotype
MGI:4358152
cx3
Allelic
Composition		 Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb2tm1Dwu mutation (1 available); any Plcb2 mutation (54 available)
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:60348 )
• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
increased immunoglobulin level ( J:60348 )
• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice

integument

hematopoietic system
abnormal neutrophil physiology ( J:60348 )
• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
increased immunoglobulin level ( J:60348 )
• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice




Genotype
MGI:4358173
cx4
Allelic
Composition		 Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: 129S1/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb2tm1Dwu mutation (1 available); any Plcb2 mutation (54 available)
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
decreased platelet calcium level ( J:60348 )
• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells
abnormal platelet physiology ( J:60348 )
• spreading of platelets on fibrinogen is impaired compared with wild-type cell
decreased platelet aggregation ( J:60348 )
• at low doses of ADP, thrombin, or collagen
decreased susceptibility to induced thrombosis ( J:60348 )
• following ferric chloride-induced arterial injury, mice fail to form arterial occlusions unlike in similarly treated wild-type mice

hematopoietic system
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
decreased platelet calcium level ( J:60348 )
• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells
abnormal platelet physiology ( J:60348 )
• spreading of platelets on fibrinogen is impaired compared with wild-type cell
decreased platelet aggregation ( J:60348 )
• at low doses of ADP, thrombin, or collagen

cellular
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory