About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plcb3tm1Dwu
targeted mutation 1, Dianqing Wu
MGI:2680661
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plcb3tm1Dwu/Plcb3tm1Dwu involves: CD-1 MGI:3715311
hm2
 		Plcb3tm1Dwu/Plcb3tm1Dwu Not Specified MGI:4358153
cx3
 		Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu 		involves: 129S1/Sv MGI:4358152
cx4
 		Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu 		involves: 129S1/Sv * CD-1 MGI:4358173


Genotype
MGI:3715311
hm1
Allelic
Composition		 Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
analgesia ( J:57478 )
• mutants are more sensitive to antinociceptive effects of morphine than wild-type mice
• mutants show a 5-fold increased sensitivity to morphine as measured by antinociception in hot plate tail-flick assay

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:66819 )
• in response to somatostatin, there is no influx of calcium measured in aortic smooth muscle cells in mutants compared to wild-type cells which show show an increased calcium level




Genotype
MGI:4358153
hm2
Allelic
Composition		 Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
spontaneous skin ulceration ( J:60348 )
• at 6 months or older behind the ears, on the next, or sometimes on the face




Genotype
MGI:4358152
cx3
Allelic
Composition		 Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb2tm1Dwu mutation (1 available); any Plcb2 mutation (54 available)
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:60348 )
• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
increased immunoglobulin level ( J:60348 )
• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice

integument

hematopoietic system
abnormal neutrophil physiology ( J:60348 )
• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
increased immunoglobulin level ( J:60348 )
• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice




Genotype
MGI:4358173
cx4
Allelic
Composition		 Plcb2tm1Dwu/Plcb2tm1Dwu
Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic
Background		 involves: 129S1/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb2tm1Dwu mutation (1 available); any Plcb2 mutation (54 available)
Plcb3tm1Dwu mutation (1 available); any Plcb3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
decreased platelet calcium level ( J:60348 )
• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells
abnormal platelet physiology ( J:60348 )
• spreading of platelets on fibrinogen is impaired compared with wild-type cell
decreased platelet aggregation ( J:60348 )
• at low doses of ADP, thrombin, or collagen
decreased susceptibility to induced thrombosis ( J:60348 )
• following ferric chloride-induced arterial injury, mice fail to form arterial occlusions unlike in similarly treated wild-type mice

hematopoietic system
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
decreased platelet calcium level ( J:60348 )
• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells
abnormal platelet physiology ( J:60348 )
• spreading of platelets on fibrinogen is impaired compared with wild-type cell
decreased platelet aggregation ( J:60348 )
• at low doses of ADP, thrombin, or collagen

cellular
increased platelet ATP level ( J:60348 )
• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory