All Phenotypes Capg<tm1Djk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Capg^tm1Djk
targeted mutation 1, David J Kwiatkowski
MGI:2680796

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capg^tm1Djk/Capg^tm1Djk	involves: 129S4/SvJae	MGI:2680798
hm2	Capg^tm1Djk/Capg^tm1Djk	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:2680801
cx3	Capg^tm1Djk/Capg^tm1Djk Gsn^tm1Djk/Gsn^tm1Djk	involves: 129S4/SvJae	MGI:3842747

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type

• macrophages increase ruffling activity in response to Salmonella exposure but the vassal and maximal ruffling activities are lower than in wild-type macrophages

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

hematopoietic system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type

• macrophages increase ruffling activity in response to Salmonella exposure but the vassal and maximal ruffling activities are lower than in wild-type macrophages

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

cellular

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

abnormal dendritic cell physiology ( J:86277 )

• mutant bone marrow-derived dendritic cells show a reduction in the ruffling response when unstimulated or stimulated with granulocyte-macrophage colony-stimulating factor compared to wild-type cells

increased susceptibility to bacterial infection ( J:86277 )

• increase in susceptibility to Listeria monocytogenes infection but not to Salmonella enterica infection

• increase in susceptibility is attributed to defects in immune cell motility

cellular

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

hematopoietic system

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk Gsn^tm1Djk/Gsn^tm1Djk
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (17 available)
Gsn^tm1Djk mutation (3 available); any Gsn mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type; seen to a similar extent as in single Capg homozygotes

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

hematopoietic system

abnormal macrophage physiology ( J:86517 )

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

cellular

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

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