All Phenotypes Capg<tm1Djk> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Capg^tm1Djk
targeted mutation 1, David J Kwiatkowski
MGI:2680796

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capg^tm1Djk/Capg^tm1Djk	involves: 129S4/SvJae	MGI:2680798
hm2	Capg^tm1Djk/Capg^tm1Djk	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:2680801
cx3	Capg^tm1Djk/Capg^tm1Djk Gsn^tm1Djk/Gsn^tm1Djk	involves: 129S4/SvJae	MGI:3842747

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type

• macrophages increase ruffling activity in response to Salmonella exposure but the vassal and maximal ruffling activities are lower than in wild-type macrophages

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

hematopoietic system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type

• macrophages increase ruffling activity in response to Salmonella exposure but the vassal and maximal ruffling activities are lower than in wild-type macrophages

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

cellular

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a 50% impairment of IgG and complement-opsonized phagocytosis and lanthanum-induced vesicle rocketing

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

abnormal dendritic cell physiology ( J:86277 )

• mutant bone marrow-derived dendritic cells show a reduction in the ruffling response when unstimulated or stimulated with granulocyte-macrophage colony-stimulating factor compared to wild-type cells

increased susceptibility to bacterial infection ( J:86277 )

• increase in susceptibility to Listeria monocytogenes infection but not to Salmonella enterica infection

• increase in susceptibility is attributed to defects in immune cell motility

cellular

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

hematopoietic system

impaired neutrophil chemotaxis ( J:86277 )

• bone marrow-derived neutrophils migrate at a mean spead that is about 50% lower than in wild-type

impaired macrophage phagocytosis ( J:86277 )

• bone marrow-derived macrophages show a 50% reduction in the rate of phagocytosis of Listeria, but a normal rate of phagocytosis of Salmonella

Allelic Composition	Capg^tm1Djk/Capg^tm1Djk Gsn^tm1Djk/Gsn^tm1Djk
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capg^tm1Djk mutation (2 available); any Capg mutation (18 available)
Gsn^tm1Djk mutation (3 available); any Gsn mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:86517 )

• macrophages exhibit a decrease in spontaneous ruffling and do not show an increase in ruffling in response to macrophage colony stimulating factor (MCSF) as observed in wild-type; seen to a similar extent as in single Capg homozygotes

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

hematopoietic system

abnormal macrophage physiology ( J:86517 )

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

cellular

impaired macrophage phagocytosis ( J:86517 )

• macrophages exhibit a similar impairment of IgG, and complement-opsonized phagocytosis as seen in single Capg homozygotes

• macrophages exhibit a higher velocity of lanthanum-induced vesicle rocketing than seen in single Capg homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24