mortality/aging
N |
• more Nxf1Mvb1-CAST/Ei homozygotes are generated from a cross betwen Eya1bor and Nxf1Mvb1-CAST/Ei mice than non-Nxf1Mvb1-CAST/Ei homozygotes
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Allele Symbol Allele Name Allele ID |
Nxf1Mvb1 modifier of vibrator 1 MGI:2680965 |
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Summary |
10 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• more Nxf1Mvb1-CAST/Ei homozygotes are generated from a cross betwen Eya1bor and Nxf1Mvb1-CAST/Ei mice than non-Nxf1Mvb1-CAST/Ei homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• no abnormalities are detected in the brains stem or spinal cord
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the auditory brainstem threshold is increased compared to wild-type mice but intermediate between Eya1bor Nxf1Mvb1-C57BL/6J and Eya1bor Nxf1Mvb1-CAST/Ei homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit less noticeable head bobbing compared to Eya1bor Nxf1Mvb1-C57BL/6J homozygotes
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• mice exhibit less noticeable circling compared to Eya1bor Nxf1Mvb1-C57BL/6J homozygotes
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• the auditory brainstem threshold is increased compared to wild-type mice but less than that of Eya1bor Nxf1Mvb1-C57BL/6J homozygotes
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• 6 of 12 mice have a loss of spiral ganglion cells in the apical turn of the cochlea
• 3 of 12 mice have more severe phenotypes
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N |
• mice do not exhibit kidney defects or associated mortality as in Eya1bor homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Ap3d1mh-2J/Ap3d1mh-2J coat color dilution is attenuated in Ap3d1mh-2J/Ap3d1mh-2J Nxf1Mvb1/Nxf1Mvb1 mice
• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes
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• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• elimination of the tendency to jump out of open fields in behavior tests displayed by Ap3d1mh-2J single homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• improved survival compared with Nxf1Mvb1-C57BL/6J/Nxf1Mvb1-CAST/Ei Pitpnavb/Pitpnavb mice
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• reduced tremor score compared with Nxf1Mvb1-C57BL/6J/Nxf1Mvb1-CAST/Ei Pitpnavb/Pitpnavb mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• lethality observed in Pitpnavb mice is suppressed with mice living past 750 days compared to less than 100 days in Pitnavb homozygotes
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• fewer neurons with pathologies were observed than in Pitpnavb/Pitpnavb Nxf1Mvb1-CAST/Ei/Nxf1Mvb1-C57BL/6J mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lethality observed in Pitpnavb mice is suppressed with mice living past 500 days compared to less than 100 days in Pitnavb homozygotes and more than 750 days in Pitnavb Nxf1mvb1-CAST/Ei homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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