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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dicer1tm1Ghan
targeted mutation 1, Gregory J Hannon
MGI:2681012
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dicer1tm1Ghan/Dicer1tm1Ghan involves: 129S7/SvEvBrd MGI:2681013


Genotype
MGI:2681013
hm1
Allelic
Composition		 Dicer1tm1Ghan/Dicer1tm1Ghan
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Ghan mutation (0 available); any Dicer1 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:86391 )
• mice died during early development, on or around E7.5

embryo
embryonic growth arrest ( J:86391 )
• arrest of development prior to body plan configuration during gastrulation
decreased embryo size ( J:86391 )
• small embryos at E7.5, however distinctions between embryonic and extraembryonic regions were recognizable

growth/size/body
decreased embryo size ( J:86391 )
• small embryos at E7.5, however distinctions between embryonic and extraembryonic regions were recognizable




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory