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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmp8tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:2681103
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ MGI:4367713
hm2
 		Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ * C57BL/6 MGI:3785290
hm3
 		Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ * C57BL/6J MGI:2681109
cx4
 		Mmp8tm1Otin/Mmp8tm1Otin
Mmp9tm1Tvu/Mmp9tm1Tvu 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:3785292


Genotype
MGI:4367713
hm1
Allelic
Composition		 Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:148442 )
N
• mice exhibit normal response to Coxsackievirus B3 (CVB3) infection




Genotype
MGI:3785290
hm2
Allelic
Composition		 Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113463 )
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis




Genotype
MGI:2681109
hm3
Allelic
Composition		 Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:86393 )
• succeptibility to tumor induction significantly greater in males than in females and latency is shorter
• ovarectomy or tamoxifen treatment increased skin cancer incidence in females
• rate of progression from benign to malignant was normal
increased fibrosarcoma incidence ( J:86393 )
• formed in response to intradermal injection of methylcholanthrene
• all were invasive tumors
increased papilloma incidence ( J:86393 )
• formed in response to DMBA+TPA

immune system
abnormal inflammatory response ( J:86393 )
• inflammatory response slower to establish itself
chronic inflammation ( J:86393 )
• sustained inflammatory response to injected carcinogens develops
• accumulated cells were neutrophils
increased susceptibility to bacterial infection ( J:97118 )
• intratracheal lipopolysaccharide (LPS) treatment results in 2 fold increase in polymorphonuclear cell accumulation in the alveolar space and approximately 3 fold increase in myeloperoxidase activity in bronchioalveolar lavage lysate




Genotype
MGI:3785292
cx4
Allelic
Composition		 Mmp8tm1Otin/Mmp8tm1Otin
Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (27 available)
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113463 )
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory