Phenotypes associated with this allele

• Allele Symbol: Ncdn^tm1Afu
• Allele Name: targeted mutation 1, Akiyoshi Fukamizu
• Allele ID: MGI:2681104
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncdn^tm1Afu/Ncdn^tm1Afu	involves: C57BL/6 * CBA	MGI:2681110
ht2	Ncdn^tm1Afu/Ncdn^+	involves: C57BL/6 * CBA	MGI:2681111

Genotype
MGI:2681110

hm1

• Allelic Composition: Ncdn^tm1Afu/Ncdn^tm1Afu
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:86413 )

• death between implantation and E6.5

embryo

abnormal embryo development ( J:86413 )

• while cultured embryos developed normally to the blastocyst stage and formed a normal inner cell mass, resorption was evident prior to E6.5

Genotype
MGI:2681111

ht2

• Allelic Composition: Ncdn^tm1Afu/Ncdn⁺
• Genetic Background: involves: C57BL/6 * CBA

skeleton

abnormal long bone hypertrophic chondrocyte zone ( J:86413 )

• non-hypertrophied cells in the hypertrophic zone of articular cartilage

abnormal long bone epiphysis morphology ( J:86413 )

• occasional partial collapse of cartilaginous columns

• residual epiphyseal cartilaginous islets

abnormal intervertebral disk morphology ( J:86413 )

• occasional partial collapse of cartilaginous columns

abnormal chondrocyte morphology ( J:86413 )

• impaired proliferation and differentiation