Phenotypes associated with this allele

• Allele Symbol: In(7Oca2;7Sox6)100H
• Allele Name: inversion, Chr 7, Harwell 100
• Allele ID: MGI:2681117
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	In(7Oca2;7Sox6)100H/In(7Oca2;7Sox6)100H	Not Specified	MGI:2681119

Genotype
MGI:2681119

hm1

• Allelic Composition: In(7Oca2;7Sox6)100H/In(7Oca2;7Sox6)100H
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Blood and liver phenotype of wild type and In(7Oca2;7Sox6)100H/In(7Oca2;7Sox6)100H mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:61682 , J:115753 )

• approximately half die within 24 hours of birth (J:61682)

postnatal lethality, complete penetrance ( J:61682 )

• mice that survive the first day after birth die within several weeks

cardiovascular system

abnormal myocardial fiber morphology ( J:61682 )

atrioventricular block ( J:61682 )

• progressive atrioventricular heart block that is putatively the cause of postnatal lethality

growth/size/body

decreased body weight ( J:61682 )

• surviving mice are approximately one-third the weight of wild-type at 14 days of age

postnatal growth retardation ( J:61682 )

muscle

abnormal myocardial fiber morphology ( J:61682 )

abnormal skeletal muscle morphology ( J:61682 )

hematopoietic system

abnormal definitive hematopoiesis ( J:115753 )

• liver shows a significant increase in hematopoietic precursor cells including nucleated erythrocytes at E18.5

increased nucleated erythrocyte cell number ( J:115753 )

• increased numbers of nucleated red cells than in wild-type at E14.5 and E18.5, however at P10.5, circulating nucleated red cells are not seen, suggesting a transient effect

liver/biliary system

abnormal liver morphology ( J:115753 )

• liver shows a significant increase in hematopoietic precursor cells including nucleated erythrocytes at E18.5