digestive/alimentary system
• mutants exhibit delayed triglyceride absorption after feeding but no difference in overall fat absorption
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• mutants exhibit a significant decrease in the rate of cholesterol absorption as well as the amount of cholesterol absorbed from a single meal
• majority of fat absorption occurs in the distal intestinal segments instead of the proximal intestinal segments as in wild-type, with a significant level occurring in the terminal ileum
• intestinal uptake of cholesterol is significantly decreased in segments 1 and 2 of the intestine but no changes in the distal portions of the intestine when compared with wild-type mice
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• 45% decrease in the amount of cholesterol in feces collected over a 24 hour period, indicating decreased absorption of cholesterol through the intestine
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homeostasis/metabolism
• mutants exhibit delayed triglyceride absorption after feeding but no difference in overall fat absorption
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• mutants exhibit a significant decrease in the rate of cholesterol absorption as well as the amount of cholesterol absorbed from a single meal
• majority of fat absorption occurs in the distal intestinal segments instead of the proximal intestinal segments as in wild-type, with a significant level occurring in the terminal ileum
• intestinal uptake of cholesterol is significantly decreased in segments 1 and 2 of the intestine but no changes in the distal portions of the intestine when compared with wild-type mice
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• 45% decrease in the amount of cholesterol in feces collected over a 24 hour period, indicating decreased absorption of cholesterol through the intestine
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• mutants exhibit a difference in the composition of minor bile acids, with a decrease in the amount of taurochenodeoxycholate and an increase in taurodeoxycholate compared to wild-type, however no differences in the cholesterol/bile acid ratio
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