Analysis Tools
mortality/aging
|
• about 75% of mice born die within 3 days
• less than 25% survived to adulthood
• survivors have a normal life span
|
|
• very few mice born
|
cellular
|
• mouse embryo fibroblast growth slowed considerably
• fewer cells in S phase
• larger numbers of cells in G0 or G1
|
 |
• total absence of post meiotic cells
• failure in prophase I probably in zygotene stage
|
|
• reduced rate of DNA replication
|
endocrine/exocrine glands
 |
• lack oocytes and follicles
|
small ovary
(
J:85942
)
|
|
• ovaries are small and grossly malformed
|
|
|
• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
|
small testis
(
J:85942
)
|
|
|
growth/size/body
|
• mice that survive to adulthood are 50-55% normal size
• major organs are proportional
|
immune system
| N |
• thymic and periferral lymphocytes normal
|
limbs/digits/tail
curly tail
(
J:85942
)
|
• tail flexion anomalies similar to curly-tail (ct) mice
|
reproductive system
|
|
• lack oocytes and follicles
|
small ovary
(
J:85942
)
|
|
• ovaries are small and grossly malformed
|
|
|
• total absence of post meiotic cells
• failure in prophase I probably in zygotene stage
|
|
|
• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
|
small testis
(
J:85942
)
|
|
|
homeostasis/metabolism
|
• reduced rate of DNA replication
|
