Phenotypes associated with this allele

• Allele Symbol: Camkk2^tm1Kpg
• Allele Name: targeted mutation 1, K Peter Giese
• Allele ID: MGI:2681319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camkk2^tm1Kpg/Camkk2^tm1Kpg	involves: 129S1/Sv * 129X1/SvJ	MGI:4946519
hm2	Camkk2^tm1Kpg/Camkk2^tm1Kpg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2681331

Genotype
MGI:4946519

hm1

• Allelic Composition: Camkk2^tm1Kpg/Camkk2^tm1Kpg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:170130 )

N • energy homeostasis and glucose handling are normal

Genotype
MGI:2681331

hm2

• Allelic Composition: Camkk2^tm1Kpg/Camkk2^tm1Kpg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

impaired social transmission of food preference ( J:86370 )

• impaired long-term, but not short-term, memory for the social transmission of food preference

• long-term memory formation for cued, contextual, and trace fear conditioning and in passive avoidance are not impaired

abnormal spatial learning ( J:86370 )

• spatial long term memory formation is delayed

• mutants spend less time in the target quadrant than wild-type, search randomly, and spend similar times in all quadrants in the hidden platform Morris water maze, however overtraining results in normal spatial long term memory

nervous system

abnormal long-term potentiation ( J:86370 )

• lack of late, but not early, long term potentiation at the CA1 synapse