Phenotypes associated with this allele

• Allele Symbol: Rarg^tm1Blt
• Allele Name: targeted mutation 1, Horst Bluethmann
• Allele ID: MGI:2681395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rarg^tm1Blt/Rarg^tm1Blt	involves: 129P2/OlaHsd * C57BL/6J	MGI:3720007

Genotype
MGI:3720007

hm1

• Allelic Composition: Rarg^tm1Blt/Rarg^tm1Blt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:27473 )

• about 40% of mortality rate after 3 month of age

growth/size/body

decreased body weight ( J:27473 )

• growth deficiencies ranging from 40 to 90% of the weight of the control

endocrine/exocrine glands

squamous metaplasia of prostate gland ( J:27473 )

♂ • squamous metaplasia of the seminal vesicles and the prostate gland with variable penetrance

squamous metaplasia of seminal vesicles ( J:27473 )

♂ • squamous metaplasia of the seminal vesicles and the prostate gland with variable penetrance

abnormal Harderian gland morphology ( J:27473 )

• absence of the epithelium of Harderian glands with variable penetrance

reproductive system

squamous metaplasia of prostate gland ( J:27473 )

♂ • squamous metaplasia of the seminal vesicles and the prostate gland with variable penetrance

squamous metaplasia of seminal vesicles ( J:27473 )

♂ • squamous metaplasia of the seminal vesicles and the prostate gland with variable penetrance

reduced male fertility ( J:27473 )

♂ • most males are infertile, but some of the males are fertile with a reduced number of progeny

respiratory system

fused tracheal cartilage rings ( J:27473 )

skeleton

fused tracheal cartilage rings ( J:27473 )

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:27473 )

• resistance to the observed adverse toxic effects, such as weight loss, hair loss, and skin scaling, with high retinoids administration