Phenotypes associated with this allele

• Allele Symbol: Igh-J^{tm1(VDJ-KL25)Zbz}
• Allele Name: targeted mutation 1, Universitatsspital Zurich, Biologisches Zentrallaboratorium
• Allele ID: MGI:2681436
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh-J^tm1(VDJ-KL25)Zbz/Igh-J^+	involves: C57BL/6 * C57BL/6J * BALB/cJ	MGI:2681461

Genotype
MGI:2681461

ht1

• Allelic Composition: Igh-J^{tm1(VDJ-KL25)Zbz}/Igh-J⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG level ( J:86411 )

• isotype switching occured at day 4

• after day 12 almost all neutralizing activity was in IgG

increased IgM level ( J:86411 )

• a dramitic, short-lived neutralizing IgM response was induced by LCMV infection but not in wild-type mice

• IgM production is largely T-cell independent

hematopoietic system

increased IgG level ( J:86411 )

• isotype switching occured at day 4

• after day 12 almost all neutralizing activity was in IgG

increased IgM level ( J:86411 )

• a dramitic, short-lived neutralizing IgM response was induced by LCMV infection but not in wild-type mice

• IgM production is largely T-cell independent