Phenotypes associated with this allele

• Allele Symbol: Igh-J^{tm1(VDJ-VI10)Zbz}
• Allele Name: targeted mutation 1, Universitatsspital Zurich, Biologisches Zentrallaboratorium
• Allele ID: MGI:2681437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh-J^tm1(VDJ-VI10)Zbz/Igh-J^+	involves: C57BL/6 * C57BL/6J * BALB/cJ	MGI:2681465

Genotype
MGI:2681465

ht1

• Allelic Composition: Igh-J^{tm1(VDJ-VI10)Zbz}/Igh-J⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune serum protein physiology ( J:86411 )

• high levels of VSV neutralizing antibodies are found in preimmunized mice (containing equal amounts of IgM and IgG)

• mice mounted a significant and faster response to infection

• titers don't reach levels seen in wild-type mice

• augmentation of isotype switching does not occur before day 6