About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pmaip1tm1Ast
targeted mutation 1, Andreas Strasser
MGI:2681649
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pmaip1tm1Ast/Pmaip1tm1Ast C57BL/6-Pmaip1tm1Ast MGI:2681656
hm2
 		Pmaip1tm1Ast/Pmaip1tm1Ast involves: C57BL/6 MGI:3815011
cx3
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Pmaip1tm1Ast/Pmaip1tm1Ast 		involves: 129S1/Sv * C57BL/6 MGI:3720170


Genotype
MGI:2681656
hm1
Allelic
Composition		 Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 C57BL/6-Pmaip1tm1Ast
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:86466 )
• modest but significant resistance to etoposide induced apoptosis in mouse embryo fibroblasts but not in thymocytes and other lymphocytes

immune system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells

hematopoietic system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells




Genotype
MGI:3815011
hm2
Allelic
Composition		 Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:132819 )
N
• no abnormalities are detected in T cell numbers after HSV-1 infection

nervous system
nervous system phenotype ( J:127640 )
N
• unlike mice homozygous for Bbc3tm1Ast neuron sensitivity to oxidative stressor induced apoptosis is similar to controls




Genotype
MGI:3720170
cx3
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Pmaip1tm1Ast mutation (1 available); any Pmaip1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells and Bcl2l11tm1.1Ast homozygotes

hematopoietic system
abnormal NK cell morphology ( J:123409 )
• following expansion in culture, NK cells survive IL-15 withdrawal better than wild-type cells and Bcl2l11tm1.1Ast homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory