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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bbc3tm1Ast
targeted mutation 1, Andreas Strasser
MGI:2681654
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bbc3tm1Ast/Bbc3tm1Ast C57BL/6-Bbc3tm1Ast MGI:3815007
hm2
Bbc3tm1Ast/Bbc3tm1Ast involves: C57BL/6 * NZB MGI:3815008
cx3
Bbc3tm1Ast/Bbc3tm1Ast
Tg(SOD1*G93A)1Gur/0
involves: C57BL/6 * NZB * SJL MGI:3815033


Genotype
MGI:3815007
hm1
Allelic
Composition
Bbc3tm1Ast/Bbc3tm1Ast
Genetic
Background
C57BL/6-Bbc3tm1Ast
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbc3tm1Ast mutation (1 available); any Bbc3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• thymocytes and MEFs show enhanced resistance to genotoxic damage induced by etoposide or gamma irradiation




Genotype
MGI:3815008
hm2
Allelic
Composition
Bbc3tm1Ast/Bbc3tm1Ast
Genetic
Background
involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbc3tm1Ast mutation (1 available); any Bbc3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• espite abnormalities in T cell survival, viral clearance is similar to controls and no abnormalities are detected in T cell activation or proliferation
• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in total leukocyte numbers compared to controls
• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in CD8+ T cell numbers compared to controls
• at 2 and 4 weeks after infection mice show a 2- to 4-fold increase in numbers of Kb-gB+ CD8+ T cells compared to controls
• however, CD8+ T cell numbers in nonlymphoid organs are normal
• at 2 and 4 weeks after infection mice an increase in the percentage of Kb-gB+ CD8+ T cells compared to controls
• HSV-1 antigen specific CD8+ T cells show enhanced survival when cultured in the absence of cytokines

nervous system
• treatment of neurons with oxidative stressors induced less apoptosis compared to controls and treated neurons retain normal voltage dependent current activity unlike controls (J:127640)
• motor neurons show decreased sensitivity to tunicamycin but not to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazoleprpionic acid (AMPA) (J:130581)

hematopoietic system
• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in total leukocyte numbers compared to controls
• at 2 and 4 weeks after infection with HSV-1, mice show a significant increase in CD8+ T cell numbers compared to controls
• at 2 and 4 weeks after infection mice show a 2- to 4-fold increase in numbers of Kb-gB+ CD8+ T cells compared to controls
• however, CD8+ T cell numbers in nonlymphoid organs are normal
• at 2 and 4 weeks after infection mice an increase in the percentage of Kb-gB+ CD8+ T cells compared to controls
• HSV-1 antigen specific CD8+ T cells show enhanced survival when cultured in the absence of cytokines




Genotype
MGI:3815033
cx3
Allelic
Composition
Bbc3tm1Ast/Bbc3tm1Ast
Tg(SOD1*G93A)1Gur/0
Genetic
Background
involves: C57BL/6 * NZB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbc3tm1Ast mutation (1 available); any Bbc3 mutation (19 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• despite the delay in disease progression, lifespan is similar to transgenic mice wild type for Bbc3

nervous system
• gliosis and microglial activation in the spinal cord at 90 days of age are reduced compared to transgenic mice wild type for Bbc3
• however, by the end stage of the disease, gliosis and microglial activation are similar to transgenic mice wild type for Bbc3
• significant delay in motor neuron loss compared to transgenic mice wild type for Bbc3
• however, in older mice with end stage disease motor neuron loss in not different from transgenic mice wild type for Bbc3

behavior/neurological
N
• unlike transgenic mice wild type for Bbc3, no decrease in stride length is seen even at 120 days of age
• decline in paw grip endurance beginning at 98 days of age compared to 77 days of age in transgenic mice wild type for Bbc3

growth/size/body
• body weight begins to significantly decrease at 105 days of age compared to 77 days of age in transgenic mice wild type for Bbc3





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory