Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rps20Mhdadsk4 Martin Hrabe de Angelis dark skin 4 MGI:2681787 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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• adults show excess epidermal pigmentation in the footpads, tail and ears
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• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
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• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
|
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• adults show excess epidermal pigmentation in the footpads, tail and ears
|
|
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age
(J:86685)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice
(J:139244)
|
|
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
|
|
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
|
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• adult mice exhibit reversal of the hyperpigmentation phenotype seen in the footpad and tail skin of single Rps20Mhdadsk4 heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis
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• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5
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• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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