Phenotypes associated with this allele

• Allele Symbol: Ghrl^tm1Rgs
• Allele Name: targeted mutation 1, Roy G Smith
• Allele ID: MGI:2681803
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ghrl^tm1Rgs/Ghrl^tm1Rgs	involves: 129/Sv * C57BL/6	MGI:2681883
hm2	Ghrl^tm1Rgs/Ghrl^tm1Rgs	involves: C57BL/6J	MGI:6102943

Genotype
MGI:2681883

hm1

• Allelic Composition: Ghrl^tm1Rgs/Ghrl^tm1Rgs
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:86432 )

• homozygotes were essentially normal for all phenotypic characteristics examined including growth, appetite, blood chemistry, and reproduction

Genotype
MGI:6102943

hm2

• Allelic Composition: Ghrl^tm1Rgs/Ghrl^tm1Rgs
• Genetic Background: involves: C57BL/6J

behavior/neurological

abnormal sleep behavior ( J:151960 )

• sleep deficit when subjected to cold and fasting challenge

• during the first 1 to 6 hours of the fasting day under cold conditions, mice exhibit reduced and fragmented NREMS and reduced REMS compared with wild-type mice

• during hours 7 through 16 of fasting under cold conditions, mice exhibit disrupted sleep with increased NREMS compared with the first phase while still being fragmented

• during hours 17 through 24 of fasting under cold conditions, mice exhibit suppressed NREMS and almost complete absence of REMS compared with wild-type mice

• no NREMS or REMS bouts are observed in the last 3 hours of a 24 hour fast under cold conditions

• however, mice subjected to a fast alone exhibit normal body temperature responses

abnormal non-rapid eye movement sleep pattern ( J:151960 )

• reduced with shortened episodes when subjected to cold

homeostasis/metabolism

impaired adaptive thermogenesis ( J:151960 )

• when subjected to cold and fasting challenge

decreased body temperature ( J:151960 )

• during hours 7 through 24 of fasting under cold conditions