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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tas1r2tm1Csz
targeted mutation 1, Charles S Zuker
MGI:2681886
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tas1r2tm1Csz/Tas1r2tm1Csz involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2681895
cx2
 		Tas1r2tm1Csz/Tas1r2tm1Csz
Tas1r3tm1Csz/Tas1r3tm1Csz 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2681900


Genotype
MGI:2681895
hm1
Allelic
Composition		 Tas1r2tm1Csz/Tas1r2tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tas1r2tm1Csz mutation (1 available); any Tas1r2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal sweet taste sensitivity ( J:86474 )
• complete loss of response to artificial sweeteners and D-amino acid, but show small neural responses to high concentrations of natural sugars
• normal morphology and numbers of taste receptor cells

nervous system
abnormal somatic nervous system physiology ( J:86474 )
• sweet tastants elicited diminished nerve response




Genotype
MGI:2681900
cx2
Allelic
Composition		 Tas1r2tm1Csz/Tas1r2tm1Csz
Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tas1r2tm1Csz mutation (1 available); any Tas1r2 mutation (50 available)
Tas1r3tm1Csz mutation (1 available); any Tas1r3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal sweet taste sensitivity ( J:86474 )
• no attraction to either natural or artificial sweetners, indicating abolished sweet taste
• normal detection of umami tastes

nervous system
abnormal somatic nervous system physiology ( J:86474 )
• no nerve response to sweet tastants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory