Phenotypes associated with this allele

• Allele Symbol: Tas1r3^tm1Csz
• Allele Name: targeted mutation 1, Charles S Zuker
• Allele ID: MGI:2681887
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tas1r3^tm1Csz/Tas1r3^tm1Csz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2681897
cx2	Tas1r2^tm1Csz/Tas1r2^tm1Csz Tas1r3^tm1Csz/Tas1r3^tm1Csz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2681900

Genotype
MGI:2681897

hm1

• Allelic Composition: Tas1r3^tm1Csz/Tas1r3^tm1Csz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal sweet taste sensitivity ( J:86474 )

• loss of behavioral attraction to sweet tastants

• complete loss of response to artificial sweeteners and D-amino acid but show small neural responses to high concentrations of natural sugers

• normal morphology and numbers of taste receptor cells

abnormal umami taste sensitivity ( J:86474 )

• loss of behavioral attraction to umami tastants

nervous system

abnormal somatic nervous system physiology ( J:86474 )

• diminished nerve response elicited by sweet and umami tastants

Genotype
MGI:2681900

cx2

• Allelic Composition: Tas1r2^tm1Csz/Tas1r2^tm1Csz; Tas1r3^tm1Csz/Tas1r3^tm1Csz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

taste/olfaction

abnormal sweet taste sensitivity ( J:86474 )

• no attraction to either natural or artificial sweetners, indicating abolished sweet taste

• normal detection of umami tastes

nervous system

abnormal somatic nervous system physiology ( J:86474 )

• no nerve response to sweet tastants