All Phenotypes S1pr1<tm2Rlp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

S1pr1^tm2Rlp
targeted mutation 2, Richard L Proia
MGI:2681911

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S1pr1^tm2Rlp/S1pr1^tm2Rlp	involves: 129S6/SvEvTac	MGI:2681963
cn2	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ S1pr1^tm2Rlp/S1pr1^tm2Rlp Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:5445987
cn3	S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/?	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:2681954

Allelic Composition	S1pr1^tm2Rlp/S1pr1^tm2Rlp
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1^tm2Rlp mutation (2 available); any S1pr1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:86450 )

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ S1pr1^tm2Rlp/S1pr1^tm2Rlp Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (1006 available)
S1pr1^tm2Rlp mutation (2 available); any S1pr1 mutation (32 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aorta morphology ( J:189010 )

• glomeruloid lesions form when tamoxifen is administered throughout pregnancy, although these lesions are less severe than in germ line null mice

abnormal retina vasculature morphology ( J:189010 )

• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment

vision/eye

abnormal retina vasculature morphology ( J:189010 )

• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment

Allelic Composition	S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1^tm1Rlp mutation (1 available); any S1pr1 mutation (32 available)
S1pr1^tm2Rlp mutation (2 available); any S1pr1 mutation (32 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Discontinuous smooth muscle cell coverage around the aorta in S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:86450 )

• died before birth and by E14.5 no heartbeat is seen

cardiovascular system

abnormal cardiovascular system morphology ( J:86450 )

poor arterial differentiation ( J:86450 )

• vascular smooth muscle only on ventral side of aorta and vessels of the brain

• dorsal side of aorta incompletely covered with endothelium

abnormal aorta smooth muscle morphology ( J:106055 )

• discontinuous smooth muscle cell coverage is seen around the aorta

abnormal pericardial cavity morphology ( J:86450 )

• enlarged pericardial cavity at E12.5

abnormal cardiovascular system physiology ( J:86450 )

hemorrhage ( J:86450 )

• spots of bleeding on the body by E12.5

• by E13.5, massive bleeding was occuring

embryo

abnormal visceral yolk sac morphology ( J:86450 )

• by E12.5, yolk sac was edematous

• less blood than normal in vessels

limbs/digits/tail

abnormal limb morphology ( J:86450 )

• limbs underdeveloped and rounded at E12.5

muscle

abnormal aorta smooth muscle morphology ( J:106055 )

• discontinuous smooth muscle cell coverage is seen around the aorta

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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