Phenotypes associated with this allele

• Allele Symbol: Prnp^{tm1(PRNP)Tkit}
• Allele Name: targeted mutation 1, Tetsuyuki Kitamoto
• Allele ID: MGI:2681980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp^tm1(PRNP)Tkit/Prnp^tm1(PRNP)Tkit	Not Specified	MGI:2681992

Genotype
MGI:2681992

hm1

• Allelic Composition: Prnp^{tm1(PRNP)Tkit}/Prnp^{tm1(PRNP)Tkit}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to prion infection ( J:86603 )

• less susceptible to MM2 type sporadic Creutzfeldt-Jakob disease (CJD) and variant CJD

• completely resistant to VV2 type sporadic CJD and dura-graft associated CJD with amyloid plaque

increased susceptibility to prion infection ( J:86603 )

• highly susceptible to MM1 and MV1 type sporadic Creutzfeldt-Jakob disease (CJD), familial CJD (M232R), and dura-graft associated CJD without amyloid plaque

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Creutzfeldt-Jakob disease		DOID:11949	OMIM:123400	J:86603