Phenotypes associated with this allele

• Allele Symbol: Icam2^tm1Jcgr
• Allele Name: targeted mutation 1, Jose-Carlos Gutierrez-Ramos
• Allele ID: MGI:2682009
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icam2^tm1Jcgr/Icam2^tm1Jcgr	involves: 129S4/SvJae * C57BL/6	MGI:2682014

Genotype
MGI:2682014

hm1

• Allelic Composition: Icam2^tm1Jcgr/Icam2^tm1Jcgr
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased airway responsiveness ( J:54748 )

• bronchoconstriction in response to methacholine provocation in ovalbumin-treated mice shows that mutants exhibit prolonged and hightened airway hyperresponsiveness

immune system

abnormal eosinophil physiology ( J:54748 )

• mutants with ovalbumin-induced lung allergic inflammation exhibit delayed, but not abrogated, eosinophil accumulation in the airway lumen and prolonged presence of eosinophils in lung interstitium

hematopoietic system

abnormal megakaryocyte progenitor cell morphology ( J:54748 )

• in bone marrow, numbers of mIL-3-dependent colony forming unit-megakaryocyte (CFU-MK) are reduced

• in a single cell megakaryocyte growth assay, numbers of Il-6- and mTPO-dependent megakaryoblasts are reduced in mutants compared to wild-type

abnormal eosinophil physiology ( J:54748 )

• mutants with ovalbumin-induced lung allergic inflammation exhibit delayed, but not abrogated, eosinophil accumulation in the airway lumen and prolonged presence of eosinophils in lung interstitium