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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ift172wim
wimple
MGI:2682066
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ift172wim/Ift172wim C3.B6J-Ift172wim MGI:3027423
hm2
 		Ift172wim/Ift172wim involves: C3HeB/FeJ * C57BL/6J MGI:3580672
hm3
 		Ift172wim/Ift172wim involves: C57BL/6J MGI:4359243
ht4
 		Ift172avc1/Ift172wim involves: C57BL/6J MGI:5290082
cx5
 		Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J MGI:3027424
cx6
 		Ift172wim/Ift172wim
Smobnb/Smobnb 		involves: C57BL/6J MGI:3624270
cx7
 		Ift172wim/Ift172wim
Kif7maki/Kif7maki
Tg(Hlxb9-GFP)1Tmj/? 		involves: C57BL/6J * FVB/N MGI:4355991


Genotype
MGI:3027423
hm1
Allelic
Composition		 Ift172wim/Ift172wim
Genetic
Background		 C3.B6J-Ift172wim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:86437 )
• development is arrested at E10.5-E11.5

cardiovascular system
abnormal direction of heart looping ( J:86437 )
• polarity of heart looping reversed in approximately 40% of E9.5 embryos

embryo
absent embryonic cilia ( J:86437 )
• node cells lack cilia
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motorneurons were not expressed

nervous system
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motorneurons were not expressed

cellular
absent embryonic cilia ( J:86437 )
• node cells lack cilia




Genotype
MGI:3580672
hm2
Allelic
Composition		 Ift172wim/Ift172wim
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal left-right axis patterning ( J:98216 )
• left-right randomization

nervous system
abnormal spinal cord morphology ( J:98216 )
• dorsalized spinal cord




Genotype
MGI:4359243
hm3
Allelic
Composition		 Ift172wim/Ift172wim
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cilium morphology ( J:138139 )
• mouse embryonic fibroblasts do not generate cilia unlike wild-type cells




Genotype
MGI:5290082
ht4
Allelic
Composition		 Ift172avc1/Ift172wim
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172avc1 mutation (0 available); any Ift172 mutation (75 available)
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal motile primary cilium morphology ( J:175371 )
• severely decreased mean ventral node cilia length at E7.5

cellular
abnormal cilium morphology ( J:175371 )
• decrease in the percentage of MEFs with cilia compared to wild-type MEFs
• severely decreased cilia length on MEFs with a large population of truncated cilia and a much smaller population of full length cilia
abnormal motile primary cilium morphology ( J:175371 )
• severely decreased mean ventral node cilia length at E7.5

cardiovascular system

craniofacial
abnormal craniofacial morphology ( J:175371 )
• craniofacial abnormalities

limbs/digits/tail
abnormal limb morphology ( J:175371 )
• limb abnormalities




Genotype
MGI:3027424
cx5
Allelic
Composition		 Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic
Background		 involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available); any Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available)
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motor neurons were not expressed

embryo
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motor neurons were not expressed




Genotype
MGI:3624270
cx6
Allelic
Composition		 Ift172wim/Ift172wim
Smobnb/Smobnb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
Smobnb mutation (0 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:100466 )
• double mutants survive to E10.5-11.5

cardiovascular system
abnormal direction of heart looping ( J:100466 )
• mutants exhibit randomization of heart looping polarity

nervous system
open neural tube ( J:100466 )
• double mutants have an open neural tube at E10.5
decreased motor neuron number ( J:100466 )
• only a few motor neurons are detected in the spinal cords of mutants

embryo
open neural tube ( J:100466 )
• double mutants have an open neural tube at E10.5




Genotype
MGI:4355991
cx7
Allelic
Composition		 Ift172wim/Ift172wim
Kif7maki/Kif7maki
Tg(Hlxb9-GFP)1Tmj/?
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
Kif7maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:151965 )
• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube

embryo
abnormal neural tube morphology ( J:151965 )
• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory