Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rps19Mhdadsk3 Martin Hrabe de Angelis dark skin 3 MGI:2682230 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ~10% of adult mice exhibit a white belly spot
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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• adults show excess epidermal pigmentation in the footpads, tail and ears
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• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
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• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
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• ~10% of adult mice exhibit a white belly spot
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• adults show excess epidermal pigmentation in the footpads, tail and ears
|
|
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
|
• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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• mice show a ~10-15% reduction in birth weight relative to control mice
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• at P21, mice exhibit a significant reduction in body weight on both an inbred (C3HeB/HeJ) and a mixed genetic background
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• mice exhibit a lower red blood cell (RBC) count on both an inbred (C3HeB/HeJ) and a mixed genetic background
• ~5% and ~10% reductions in RBC count are noted at 8 weeks and 20 weeks of age, respectively
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• mice show a ~50% reduction in reticulocyte count relative to control mice
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• at 8 weeks of age, mice exhibit an increase in annexin V-positive bone marrow progenitor cells (lineage-cKit+) relative to control mice, indicating increased apoptosis
• however, bone marrow cytology is normal
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• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
|
• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• adult mice exhibit reversal of the hyperpigmentation phenotype seen in the footpad and tail skin of single Rps19Mhdadsk3 heterozygotes
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| N |
• adult mice exhibit reversal of the body weight phenotypes seen in single Rps19Mhdadsk3 heterozygotes
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• adult mice exhibit reversal of the erythrocyte phenotype seen in single Rps19Mhdadsk3 heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad
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• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis
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• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5
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• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult mice show a larger white belly spot than mice that are only heterozygous for the KitW-v allele
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• adult mice show a larger white belly spot than mice that are only heterozygous for the KitW-v allele
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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