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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt2Mhdadsk2
Martin Hrabe de Angelis dark skin 2
MGI:2682236
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt2Mhdadsk2/Krt2Mhdadsk2 involves: C3HeB/FeJ * C57BL/6J MGI:2682251
ht2
 		Krt2Mhdadsk2/Krt2+ C3HeB/FeJ-Krt2Mhdadsk2/Ieg MGI:2682252


Genotype
MGI:2682251
hm1
Allelic
Composition		 Krt2Mhdadsk2/Krt2Mhdadsk2
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt2Mhdadsk2 mutation (0 available); any Krt2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

hearing/vestibular/ear
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

craniofacial
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

integument
thick epidermis ( J:81301 )
• histologically determined in the foot pads and tail at one month of age
scaly skin ( J:81301 )
• affecting ear skin, tail and footpads
• scaling is evident by 3-4 weeks of age
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

growth/size/body
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
bullous congenital ichthyosiform erythroderma DOID:0060877 OMIM:146800
 J:81301




Genotype
MGI:2682252
ht2
Allelic
Composition		 Krt2Mhdadsk2/Krt2+
Genetic
Background		 C3HeB/FeJ-Krt2Mhdadsk2/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt2Mhdadsk2 mutation (0 available); any Krt2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

hearing/vestibular/ear
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

craniofacial
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

integument
thick epidermis ( J:81301 )
• histologically determined in the foot pads and tail at one month of age
scaly skin ( J:81301 )
• affecting ear skin, tail and footpads
• scaling is evident by 3-4 weeks of age
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

growth/size/body
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
bullous congenital ichthyosiform erythroderma DOID:0060877 OMIM:146800
 J:81301




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory