Phenotypes associated with this allele

• Allele Symbol: Egfr^Mhdadsk5
• Allele Name: Martin Hrabe de Angelis dark skin 5
• Allele ID: MGI:2682255
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfr^Mhdadsk5/Egfr^Mhdadsk5	involves: C3HeB/FeJ * C57BL/6J	MGI:2682257
ht2	Egfr^Mhdadsk5/Egfr^+	C3HeB/FeJ-Egfr^Mhdadsk5/Ieg	MGI:2682259
ht3	Egfr^Mhdadsk5/Egfr^+	involves: 129S1/SvImJ * C3HeB/FeJ	MGI:6403356

Genotype
MGI:2682257

hm1

• Allelic Composition: Egfr^Mhdadsk5/Egfr^Mhdadsk5
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

limbs/digits/tail

long toenails ( J:81301 )

• increased nail length seen in some mice

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

integument

waved hair ( J:81301 )

• slight wave to the coat becomes less apparent with age

long toenails ( J:81301 )

• increased nail length seen in some mice

thick epidermis ( J:81301 )

• histologically determined

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

Genotype
MGI:2682259

ht2

• Allelic Composition: Egfr^Mhdadsk5/Egfr⁺
• Genetic Background: C3HeB/FeJ-Egfr^Mhdadsk5/Ieg

pigmentation

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

limbs/digits/tail

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

integument

waved hair ( J:81301 )

• slight wave to the coat becomes less apparent with age

abnormal nail morphology ( J:81301 )

• increased nail length seen in some mice

thick epidermis ( J:81301 )

• histologically determined

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

Genotype
MGI:6403356

ht3

• Allelic Composition: Egfr^Mhdadsk5/Egfr⁺
• Genetic Background: involves: 129S1/SvImJ * C3HeB/FeJ

immune system

increased susceptibility to Coronaviridae infection ( J:243599 )

• mice infected with a mouse adapted (MA15) version of severe acute respiratory syndrome coronavirus (SARS-CoV) show enhanced lung damage compared to wild-type mice, showing increased perivascular inflammation with interstitial edema, and alveolar and interstitial spaces filled with proteinaceous fluid and inflammatory cells, however they show a similar weight loss, viral titer, and recovery as wild-type control mice

• aged mice (20-24 weeks old) show increased susceptibility to SARS-CoV infection compared to older wild-type mice, showing higher levels of lung damage, increased edema, perivascular cuffing, interstitial inflammation and cuffing around airways, and enhanced cellular proliferation in lungs

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:243599