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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgcrtm1Ishi
targeted mutation 1, Shun Ishibashi
MGI:2682329
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmgcrtm1Ishi/Hmgcrtm1Ishi involves: 129S7/SvEvBrd * C57BL/6J MGI:2682330
ht2
 		Hmgcrtm1Ishi/Hmgcr+ involves: 129S7/SvEvBrd * C57BL/6J MGI:2682331


Genotype
MGI:2682330
hm1
Allelic
Composition		 Hmgcrtm1Ishi/Hmgcrtm1Ishi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrtm1Ishi mutation (1 available); any Hmgcr mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:86378 )
• early lethality, embryos recovered at the blastocyst stage but not at E8.5
• mevalonate supplementation did not rescue embryos




Genotype
MGI:2682331
ht2
Allelic
Composition		 Hmgcrtm1Ishi/Hmgcr+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrtm1Ishi mutation (1 available); any Hmgcr mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:86378 )
• mice were viable, fertile, and showed normal plasma and hepatic levels of cholesterol and triglycerides as well as a normal lipoprotein profile




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory