About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgcrtm1Ishi
targeted mutation 1, Shun Ishibashi
MGI:2682329
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmgcrtm1Ishi/Hmgcrtm1Ishi involves: 129S7/SvEvBrd * C57BL/6J MGI:2682330
ht2
 		Hmgcrtm1Ishi/Hmgcr+ involves: 129S7/SvEvBrd * C57BL/6J MGI:2682331


Genotype
MGI:2682330
hm1
Allelic
Composition		 Hmgcrtm1Ishi/Hmgcrtm1Ishi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrtm1Ishi mutation (1 available); any Hmgcr mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:86378 )
• early lethality, embryos recovered at the blastocyst stage but not at E8.5
• mevalonate supplementation did not rescue embryos




Genotype
MGI:2682331
ht2
Allelic
Composition		 Hmgcrtm1Ishi/Hmgcr+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrtm1Ishi mutation (1 available); any Hmgcr mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:86378 )
• mice were viable, fertile, and showed normal plasma and hepatic levels of cholesterol and triglycerides as well as a normal lipoprotein profile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory