All Phenotypes Prnp<tm2.1Cwe> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prnp^tm2.1Cwe
targeted mutation 2.1, Charles Weissmann
MGI:2682338

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp^tm2.1Cwe/Prnp^tm2.1Cwe	involves: 129P2/OlaHsd	MGI:2682349
hm2	Prnp^tm2.1Cwe/Prnp^tm2.1Cwe	Not Specified	MGI:3047649
ht3	Prnp^tm1Cwe/Prnp^tm2.1Cwe	involves: 129P2/OlaHsd	MGI:2682350

Allelic Composition	Prnp^tm2.1Cwe/Prnp^tm2.1Cwe
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm2.1Cwe mutation (0 available); any Prnp mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:67593 )

• mice began showing tremors and trembling gait at 6 months of age with incomplete penetrance

• observed in 50% of mice around 10 months of age

• observed in 100% of mice around 13 months of age

ataxia ( J:67593 )

muscle

abnormal muscle physiology ( J:67593 )

• progressive hypotonicity of hindlimbs

• more severe than in the forelimbs

nervous system

abnormal cerebellum morphology ( J:67593 )

decreased Purkinje cell number ( J:67593 )

• age-dependent loss of Purkinje cells

• ~40% loss in vermis I-VIII at 30 weeks

• ~80% loss in vermis I-VIII at 63 weeks

• normal granular layer, indicating Purkinje cell loss was not secondary to granular layer abnormalities

thin cerebellar molecular layer ( J:67593 )

• putatively due to the loss of the dendritic structures of Purkinje cells

Allelic Composition	Prnp^tm2.1Cwe/Prnp^tm2.1Cwe
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm2.1Cwe mutation (0 available); any Prnp mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

gliosis ( J:89232 )

• homozygous mutants develop gliosis

Allelic Composition	Prnp^tm1Cwe/Prnp^tm2.1Cwe
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm1Cwe mutation (37 available); any Prnp mutation (142 available)
Prnp^tm2.1Cwe mutation (0 available); any Prnp mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:67593 )

• mice began showing ataxia and other cerebellar related phenotypes at 12 months of age

• observed in 50% of mice around 16 months of age

• observed in 100% of mice around 17 months of age

nervous system

abnormal cerebellum morphology ( J:67593 )

decreased Purkinje cell number ( J:67593 )

• age-dependent loss of Purkinje cells

• no significant loss at 30 weeks

• 30% loss at 63 weeks

• 70% loss at 95 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24