All Phenotypes Nanos2<tm1Ysa> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nanos2^tm1Ysa
targeted mutation 1, Yumiko Saga
MGI:2682606

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3702696
hm2	Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:2682626
ht3	Nanos2^tm1Ysa/Nanos2^tm3Ysa	involves: 129 * C57BL/6 * CBA * ICR	MGI:3768235
cx4	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8^tm1Ysa	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)	MGI:5561053
cx5	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8⁺	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)	MGI:5561055
cx6	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778827
cx7	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778828

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:132711 )

• male gonocytes become feminized

abnormal male germ cell morphology ( J:132711 )

• male germ cells arrest at E14.5 but unlike wild-type germ cells reinitiate proliferation from E15.5

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

cellular

abnormal male germ cell morphology ( J:132711 )

• male germ cells arrest at E14.5 but unlike wild-type germ cells reinitiate proliferation from E15.5

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:86522 )

• mutant testes were approximately 30% the weight of those of wild-type

• female gonads were morphologically and functionally normal

reproductive system

azoospermia ( J:86522 )

• ectopic and reduced numbers of germ cells were observed at E15.5

• the number of germ cells was further reduced by E18 and no germ cells were detected at 4 weeks of age

• apoptosis was observed in the testes until they were devoid of germ cells

decreased testis weight ( J:86522 )

• mutant testes were approximately 30% the weight of those of wild-type

• female gonads were morphologically and functionally normal

male infertility ( J:86522 )

• though males showed severe germ cell deficiency and were sterile, female mice were fertile

cellular

azoospermia ( J:86522 )

• ectopic and reduced numbers of germ cells were observed at E15.5

• the number of germ cells was further reduced by E18 and no germ cells were detected at 4 weeks of age

• apoptosis was observed in the testes until they were devoid of germ cells

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm3Ysa
Genetic Background	involves: 129 * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)
Nanos2^tm3Ysa mutation (0 available); any Nanos2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased male germ cell number ( J:119032 )

• at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age

abnormal seminiferous tubule morphology ( J:119032 )

• at 2 and 6 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

abnormal spermatogenesis ( J:119032 )

• at E18.5, some germ cells are localized outside of the testis cord

• at E18.5 and 1 week after birth, the number of cells undergoing apoptosis in the testes is increased compared to in wild-type mice

• however, apoptosis rates in the testes are comparable to wild-type by 3 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:119032 )

cellular

decreased male germ cell number ( J:119032 )

• at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8^tm1Ysa
Genetic Background	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)
Stra8^tm1Ysa mutation (0 available); any Stra8 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205334 )

• defective

abnormal male reproductive system physiology ( J:205334 )

• male germ cells fail to maintain mitotic arrest and re-enter the cell cycle at E15.5

cellular

abnormal male meiosis ( J:205334 )

• defective

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8⁺
Genetic Background	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205334 )

• defective

abnormal male reproductive system physiology ( J:205334 )

• male germ cells fail to maintain mitotic arrest and re-enter the cell cycle at E15.5

cellular

abnormal male meiosis ( J:205334 )

• defective

Allelic Composition	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:132711 )

• male gonocytes become feminized

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24