All Phenotypes Ets2<tm2Rgo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ets2^tm2Rgo
targeted mutation 2, Robert G Oshima
MGI:2682649

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ets2^tm2Rgo/Ets2^tm2Rgo	involves: FVB/N	MGI:2682667
ht2	Ets2^tm2Rgo/Ets2^tm5.2Rgo	involves: 129/Sv * C57BL/6 * FVB/N	MGI:4353411
ht3	Ets2^tm2Rgo/Ets2^tm1Rgo	involves: FVB/N	MGI:2682668
cn4	Ets2^tm2Rgo/Ets2^tm3Rgo Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:3769401
cx5	Ets1^tm1Jml/Ets1^tm1Jml Ets2^tm2Rgo/Ets2^tm2Rgo	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:4353402

Allelic Composition	Ets2^tm2Rgo/Ets2^tm2Rgo
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm2Rgo mutation (0 available); any Ets2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:86530 )

• transplanted mammary tumors only developed to about half the size of controls

• growth of mammary tumors resulting from trasgenic polyoma virus or transgenic Neu were similarly restricted in growth

• homozygotes are viable, fertile, and live normal life spans

Allelic Composition	Ets2^tm2Rgo/Ets2^tm5.2Rgo
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm2Rgo mutation (0 available); any Ets2 mutation (39 available)
Ets2^tm5.2Rgo mutation (0 available); any Ets2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:151187 )

• by E11.5

Allelic Composition	Ets2^tm2Rgo/Ets2^tm1Rgo
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2^tm2Rgo mutation (0 available); any Ets2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86530 )

• death occurs around E11.5

embryo

absent vitelline blood vessels ( J:86530 )

cardiovascular system

absent vitelline blood vessels ( J:86530 )

Allelic Composition	Ets2^tm2Rgo/Ets2^tm3Rgo Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm2Rgo mutation (0 available); any Ets2 mutation (39 available)
Ets2^tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:128952 )

• mice die around mid-gestation

Allelic Composition	Ets1^tm1Jml/Ets1^tm1Jml Ets2^tm2Rgo/Ets2^tm2Rgo
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1^tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2^tm2Rgo mutation (0 available); any Ets2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:151187 )

• fewer than expected embryos are seen at E11.5 with all lost before E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:151187 )

• fewer than expected embryos are seen at E11.5 with all lost before E15.5

cellular

increased vascular endothelial cell apoptosis ( J:151187 )

• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system

abnormal vascular branching morphogenesis ( J:151187 )

• striking decrease in vascular complexity at E10.5

• defect in branching is also seen at E9.5 and E11.5

• increase in inter blood vessel spacing

dilated vasculature ( J:151187 )

• dilation is often seen at E10.5 with the distinction between large and small vessels unclear

• at E11.5, some embryos have large visibly dilated blood vessels

hemorrhage ( J:151187 )

• seen at E11.5 in some embryos

increased vascular endothelial cell apoptosis ( J:151187 )

• increase in endothelial cell apoptosis at E11.5 and E13.5

homeostasis/metabolism

edema ( J:151187 )

• seen at E11.5 in some embryos

embryo

embryo phenotype ( J:151187 )

N	• in embryos without visible vascular abnormalities, no defects are detected in the placental labyrinth layer

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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