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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox3tm1.1Lja
targeted mutation 1, J Larry Jameson
MGI:2682663
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox3tm1.1Lja/Sox3tm1.1Lja involves: 129S1/Sv * 129X1/SvJ MGI:2682666
ot2
 		Sox3tm1.1Lja/Y involves: 129S1/Sv * 129X1/SvJ MGI:2682795


Genotype
MGI:2682666
hm1
Allelic
Composition		 Sox3tm1.1Lja/Sox3tm1.1Lja
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox3tm1.1Lja mutation (1 available); any Sox3 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal oocyte morphology ( J:86431 )
• ovulation of defective oocytes

behavior/neurological
behavior/neurological phenotype ( J:86431 )
N
• unlike human patients with mutations in the orthologous gene, mice did not show signs of mental retardation

skeleton
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed

craniofacial
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed

endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:86431 )
• excess follicular atresia though corpora lutea were present

growth/size/body
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed
decreased body weight ( J:86431 )
• incomplete penetrance of low body weight

reproductive system
abnormal oocyte morphology ( J:86431 )
• ovulation of defective oocytes
abnormal female reproductive system morphology ( J:86431 )
• ovaries developed, however defects associated with the formation of follicles and oocytes were observed
abnormal ovarian folliculogenesis ( J:86431 )
• excess follicular atresia though corpora lutea were present




Genotype
MGI:2682795
ot2
Allelic
Composition		 Sox3tm1.1Lja/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox3tm1.1Lja mutation (1 available); any Sox3 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

behavior/neurological
behavior/neurological phenotype ( J:86431 )
N
• unlike human patients with mutations in the orthologous gene, mice did not show signs of mental retardation

skeleton
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed

craniofacial
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed

endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:86431 )
• sertoli cell vacuolization
decreased testis weight ( J:86431 )
• testes weight was 58% that of wild-type

growth/size/body
abnormal tooth morphology ( J:86431 )
• overgrowth and misalignment of front teeth consistently observed
decreased body weight ( J:86431 )
• incomplete penetrance of low body weight

reproductive system
abnormal Sertoli cell morphology ( J:86431 )
• sertoli cell vacuolization
decreased testis weight ( J:86431 )
• testes weight was 58% that of wild-type




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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory