Phenotypes associated with this allele

• Allele Symbol: Hbegf^tm2Mek
• Allele Name: targeted mutation 2, Eisuke Mekada
• Allele ID: MGI:2682958
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hbegf^tm2Mek/Hbegf^tm2Mek	B6.Cg-Hbegf^tm2Mek	MGI:4818458
hm2	Hbegf^tm2Mek/Hbegf^tm2Mek	involves: 129/Sv * C57BL/6 * CBA	MGI:2683023

Genotype
MGI:4818458

hm1

• Allelic Composition: Hbegf^tm2Mek/Hbegf^tm2Mek
• Genetic Background: B6.Cg-Hbegf^tm2Mek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal atrioventricular valve morphology ( J:161948 )

• atrioventricular valve thickness is increased compared to in wild-type mice

abnormal heart ventricle outflow tract morphology ( J:161948 )

• outflow tract valve thickness is increased compared to in wild-type mice

Genotype
MGI:2683023

hm2

• Allelic Composition: Hbegf^tm2Mek/Hbegf^tm2Mek
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Enlarged heart with fibrosis and poor left ventricular contraction in Hbegf^tm2Mek/Hbegf^tm2Mek mice

mortality/aging

premature death ( J:86547 )

• about 50% of homozygotes survive beyond 18 weeks

cardiovascular system

abnormal cardiovascular system morphology ( J:86547 )

thin myocardium ( J:86547 )

• wall thickness reduced at 12 weeks

abnormal heart size ( J:86547 )

enlarged heart ( J:86547 )

• massively enlarged heart

abnormal heart valve morphology ( J:86547 )

enlarged atrioventricular valve ( J:86547 )

• enlarged at E17.5

enlarged semilunar valve ( J:86547 )

• enlarged at E17.5

cardiac fibrosis ( J:86547 )

• sporatic fibrosis at 12 weeks

abnormal cardiovascular system physiology ( J:86547 )

dilated cardiomyopathy ( J:86547 )

• marked dilation

decreased cardiac muscle contractility ( J:86547 )

• reduced cardiac wall movement and ventricular fractional shortening

decreased heart left ventricle muscle contractility ( J:86547 )

• poor left ventricular contractions

muscle

thin myocardium ( J:86547 )

• wall thickness reduced at 12 weeks

dilated cardiomyopathy ( J:86547 )

• marked dilation

decreased cardiac muscle contractility ( J:86547 )

• reduced cardiac wall movement and ventricular fractional shortening

decreased heart left ventricle muscle contractility ( J:86547 )

• poor left ventricular contractions

growth/size/body

enlarged heart ( J:86547 )

• massively enlarged heart