Phenotypes associated with this allele

• Allele Symbol: Nid1^tm1Dong
• Allele Name: targeted mutation 1, Lijin Dong
• Allele ID: MGI:2682959
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nid1^tm1Dong/Nid1^tm1Dong	involves: 129P2/OlaHsd	MGI:2683015

Genotype
MGI:2683015

hm1

• Allelic Composition: Nid1^tm1Dong/Nid1^tm1Dong
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:80843 )

• when removed from cages by tails, mutants distort their body into a twisted posture, with its front legs held close to its body or rigidly extend their hind legs and initiate a flailing movement; upon release, the hind legs seem temporarily paralyzed and extend behind the body

sporadic seizures ( J:80843 )

• sporadic involuntary movements resembling seizures are observed

nervous system

sporadic seizures ( J:80843 )

• sporadic involuntary movements resembling seizures are observed

cardiovascular system

abnormal capillary morphology ( J:80843 )

• thinning and discontinuity of the basement membrane in brain capillaries

muscle

abnormal muscle physiology ( J:80843 )

• under mild carbon dioxide exposure (for 5 seconds), hindlegs of mutant become rigidly extended, indicating loss of muscle control

vision/eye

abnormal lens morphology ( J:80843 )

• in the lens from a 7 week old mutant, the border between elongating fiber cells and the posterior lens capsule is highly irregular and the basement membrane is invaded by the projections from lens fiber cells

cellular

abnormal basement membrane morphology ( J:80843 )

• thinning and discontinuity of the basement membrane in brain capillaries

• the basement membrane of the posterior lens capsule is invaded by projections from lens fiber cells