Phenotypes associated with this allele

• Allele Symbol: Hbegf^tm3Mek
• Allele Name: targeted mutation 3, Eisuke Mekada
• Allele ID: MGI:2682961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hbegf^tm3Mek/Hbegf^+	involves: 129/Sv * C57BL/6 * CBA	MGI:2683024

Genotype
MGI:2683024

ht1

• Allelic Composition: Hbegf^tm3Mek/Hbegf⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:86547 )

• most chimerics displayed perinatal lethality

• survivors were fertile

• F1 heterozygotes (derived from chimerics) also showed perinatal lethality

cardiovascular system

abnormal myocardial fiber morphology ( J:86547 )

• cardiac muscle fibers are loose with large nuclei

• possibly reduced differentiation or terminated proliferation

cardiac hypertrophy ( J:86547 )

• ventricular hypertrophy seen at E16.5 and at birth

growth/size/body

cardiac hypertrophy ( J:86547 )

• ventricular hypertrophy seen at E16.5 and at birth

decreased body size ( J:86547 )

• chimerics with abnormally small bodies

• F1 phenotype even more severe

muscle

abnormal myocardial fiber morphology ( J:86547 )

• cardiac muscle fibers are loose with large nuclei

• possibly reduced differentiation or terminated proliferation

integument

thick epidermis ( J:86547 )

• chimerics have thickened skin

• F1 mice with elephant like skin

• skin transplanted to Balb/c nu/nu mice showed severe hyperplasia and large hair follicle-like structures