Phenotypes associated with this allele

• Allele Symbol: Ecsit^tm1Gho
• Allele Name: targeted mutation 1, Sankar Ghosh
• Allele ID: MGI:2683025
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecsit^tm1Gho/Ecsit^tm1Gho	involves: 129S6/SvEvTac * C57BL/6	MGI:2683026

Genotype
MGI:2683026

hm1

• Allelic Composition: Ecsit^tm1Gho/Ecsit^tm1Gho
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86912 )

• though some abnormal embryos are detected at E8.5, no mice are present at E9.5

embryo

abnormal mesoderm development ( J:86912 )

• embryonic cells transplanted into nude mice exhibit reduced teratoma formation with no differentiation into mesodermal derivates unlike ES cells from wild-type mice

decreased embryo size ( J:86912 )

• at E6.5

thick embryonic epiblast ( J:86912 )

• at E7.5 the epiblast is thicker than in wild-type mice with multiple cell layers

absent mesoderm ( J:86912 )

• at E7.5, mice lack mesoderm

cellular

decreased cell proliferation ( J:86912 )

• the number of proliferating cells in an embryo is 4-fold less than in wild-type embryos

• embryonic stem (ES) cells exhibit decreased proliferation compared to wild-type ES cells

• embryonic cells transplanted into nude mice exhibit reduced teratoma formation with no differentiation into mesodermal derivates unlike ES cells from wild-type mice

growth/size/body

decreased embryo size ( J:86912 )

• at E6.5