Phenotypes associated with this allele

• Allele Symbol: Il18^tm1Liew
• Allele Name: targeted mutation 1, Foo Yew Liew
• Allele ID: MGI:2683093
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il18^tm1Liew/Il18^tm1Liew	involves: 129P2/OlaHsd * CD-1	MGI:2683235

Genotype
MGI:2683235

hm1

• Allelic Composition: Il18^tm1Liew/Il18^tm1Liew
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon level ( J:86621 )

• IFN-gamma levels lower in spleen and lymph node cells and in serum

abnormal interleukin level ( J:86621 )

• Il-4 levels high in spleen and lymph node cells

• Il-5 levels high in spleen cells

• Il10 levels high in both spleen and lymph node cells

• Il12 levels were high in serum

abnormal tumor necrosis factor level ( J:86621 )

• lower levels in spleen cells

increased susceptibility to bacterial infection ( J:86621 )

• less septicemia in response to S. aureus infection, but more severe septic arthritis, as compared to wild-type controls

increased susceptibility to parasitic infection ( J:86621 )

• persistence of Leishmania major infections

• higher parasitic loads

• ulceration at point of infection by 40 days

sepsis ( J:86621 )

• after Staphylococcus aureus infection, much less septicemia

• more septic arthritis after S aureus infection

homeostasis/metabolism

abnormal interferon level ( J:86621 )

• IFN-gamma levels lower in spleen and lymph node cells and in serum

abnormal interleukin level ( J:86621 )

• Il-4 levels high in spleen and lymph node cells

• Il-5 levels high in spleen cells

• Il10 levels high in both spleen and lymph node cells

• Il12 levels were high in serum

abnormal tumor necrosis factor level ( J:86621 )

• lower levels in spleen cells