nervous system
N |
• homozygotes are viable, fertile and display no morphological or functional abnormalities of the nervous system relative to wild-type controls
(J:86439)
• normal numbers of motoneurons in five brain stem motor nuclei, including facial, oculomotor, hypoglossal, trigeminal motor, and trochlear nuclei
(J:86439)
• normal numbers of sensory neurons in trigeminal ganglia and L6 lumbar dorsal root ganglia
(J:86439)
• normal morphology and numbers of myelinated A-fibers and unmyelinated C-fibers in adult saphenous nerves
(J:86439)
• normal survival characteristics of P2 trigenimal ganglion neurons in various culture conditions
(J:86439)
• normal sensory recovery after chronic constriction injury (CCI) to the sciatic nerve, suggesting that nerve regeneration and plasticity of early somatosensory pathways remains intact
(J:86439)
• no significant differences in dopamine or its metabolite (DOPAC, 5-HIAA and HVA) levels in the striatum at 9 months of age
(J:92213)
|
• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity
|
• early postnatal (P5) and adult (18 months) homozygotes show a similar (15-20%) reduction in the number of tyrosine hydroxylase (TH)-positive dopaminergic neurons in substantia nigra pars compacta (SNpc) but not in ventral tegmental area (VTA) relative to wild-type controls
• however, no differences in the number of midbrain dopaminergic neurons are detected in SNpc at E18
• also, no significant decrease in the number of TH-positive dopaminergic neurons is noted in SNpc after methyl-phenyl-tetrahydropyridine (MPTP) treatment relative to controls
|
homeostasis/metabolism
• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity
|
behavior/neurological
N |
• adult male homozygotes show normal behavioral reflex responses to noxious radiant heat and graded mechanical stimuli in the CCI model of neuropathic pain
(J:86439)
• homozygotes are behaviorally normal and show no detectable motor dysfunction in either constant speed or accelerating rotarod tests
(J:92213)
|
cellular
• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity
|