Phenotypes associated with this allele

• Allele Symbol: Pparg^tm1Auw
• Allele Name: targeted mutation 1, Johan Auwerx
• Allele ID: MGI:2683406
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pparg^tm1Auw/Pparg^tm1Auw	either: 129 or C57BL/6J or (involves: 129 * C57BL/6J)	MGI:2683447

Genotype
MGI:2683447

hm1

• Allelic Composition: Pparg^tm1Auw/Pparg^tm1Auw
• Genetic Background: either: 129 or C57BL/6J or (involves: 129 * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:86705 )

• 24% died during within 1 week of birth

• greater than 40% had died by weaning

adipose tissue

abnormal brown adipose tissue morphology ( J:86705 )

• BAT was paler in color than that of wild-type and infused with lipids

decreased brown adipose tissue mass ( J:86705 )

• reduced amount of brown adipose tissue (BAT)

decreased white adipose tissue mass ( J:86705 )

• absence of white adipose tissue (WAT) at 1 week of age

lipodystrophy ( J:86705 )

• mice remained completely lipodystrophic into adulthood with the exception of small amount of subcutaneous WAT observed in some mice

growth/size/body

decreased body weight ( J:86705 )

• body weight was similar to that of wild-type at birth, but was significantly reduced at 7 days of age

• by 5 weeks of age, the weight of surviving mice was similar to that of wild-type littermates

postnatal growth retardation ( J:86705 )

• though mice actively suckled and nursed, they exhibited a reduced rate of growth during the first week of life

enlarged liver ( J:86705 )

• livers were enlarged in young mice, but not in mice that survived to adulthood

• serum ALT and AST levels were normal in adult mice, indicating normal liver functional

• no signs of inflammation or fibrosis were observed in adult livers

homeostasis/metabolism

increased circulating free fatty acids level ( J:86705 )

• increased serum FFA at 5 days of age

• the increase in FFA was less pronounced at 7 days of age

increased circulating triglyceride level ( J:86705 )

• increased serum TG at 5 days of age

• the increase in TG was less pronounced at 7 days of age

hyperlipidemia ( J:86705 )

abnormal circulating alanine transaminase level ( J:86705 )

• decreased relative to wild-type at 5 and 7 days of age

• the decrease was less pronounced at 7 days of age

increased circulating aspartate transaminase level ( J:86705 )

• elevated AST levels at 5 days of age but not at 7 days of age

decreased body temperature ( J:86705 )

• reduced body temperature relative to wild-type

abnormal glucose homeostasis ( J:86705 )

impaired glucose tolerance ( J:86705 )

insulin resistance ( J:86705 )

• mild insulin resistance

increased liver triglyceride level ( J:86705 )

• elevated hepatic TG levels in young mice, but not in mice that survived to adulthood

liver/biliary system

enlarged liver ( J:86705 )

• livers were enlarged in young mice, but not in mice that survived to adulthood

• serum ALT and AST levels were normal in adult mice, indicating normal liver functional

• no signs of inflammation or fibrosis were observed in adult livers

increased liver triglyceride level ( J:86705 )

• elevated hepatic TG levels in young mice, but not in mice that survived to adulthood

macrovesicular hepatic steatosis ( J:86705 )

• macrovesicular steatosis following an increase in liver triacylglycerides

• fatty liver was not observed in mice that survived to adulthood