Analysis Tools
endocrine/exocrine glands
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• an increase in the number of apoptotic cells is seen in mutant testis
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• collapsed tubules
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small testis
(
J:86720
)
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• approximately 50% smaller than those of wild-type
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reproductive system
azoospermia
(
J:86720
)
|
|
• the epididymides were devoid of spermatozoa
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• mutant spermatids often contain two distinct vesicles with proacrosomal granules that already made contact with the nucleus instead the normal spermatids in which the two vesicles typically fuse to a single, rounded proacrosomal vesicle prior to contacting the nuclear envelope
• mutant testis frequently shows dilated acrosomes
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• spermatids have nuclei with poorly condensed chromatin
• spermatids are abnormally shaped with numerous invaginations and kinks never seen in wild-type cells
• spermatid tail formation is impaired, as many contain the basal tail cuff at the point of insertion but fail to add axonemes to elongate the tail structure
• occasionally, more than one tail-like protrusion starts to form in several locations of mutant spermatids
• the normal location of spermatids in the apical region of the tubules is changed and spermatids appear mostly round rather than elongated
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• spermatogonia normally found at the base of the seminiferous epithelium in close association with the lamina propria are misplaced toward the lumen of tubules in mutant testis
|
|
|
• an increase in the number of apoptotic cells is seen in mutant testis
|
|
|
• collapsed tubules
|
small testis
(
J:86720
)
|
|
• approximately 50% smaller than those of wild-type
|
|
|
• spermatids failed to form normal acrosomes
|
|
|
• at P90, round and elongating spermatids are released prematurely from the epithelium and located inside the lumen of the tubules
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• spermatogonia, spermatocytes, and round spermatids are formed in seminiferous tubules, however the late transition to spermatozoa fails to occur indicating a block in late spermatid differentiation and resulting in severe reduction of mature gametes
|
cellular
azoospermia
(
J:86720
)
|
|
• the epididymides were devoid of spermatozoa
|
|
|
• mutant spermatids often contain two distinct vesicles with proacrosomal granules that already made contact with the nucleus instead the normal spermatids in which the two vesicles typically fuse to a single, rounded proacrosomal vesicle prior to contacting the nuclear envelope
• mutant testis frequently shows dilated acrosomes
|
|
|
• spermatids have nuclei with poorly condensed chromatin
• spermatids are abnormally shaped with numerous invaginations and kinks never seen in wild-type cells
• spermatid tail formation is impaired, as many contain the basal tail cuff at the point of insertion but fail to add axonemes to elongate the tail structure
• occasionally, more than one tail-like protrusion starts to form in several locations of mutant spermatids
• the normal location of spermatids in the apical region of the tubules is changed and spermatids appear mostly round rather than elongated
|
|
|
• spermatogonia normally found at the base of the seminiferous epithelium in close association with the lamina propria are misplaced toward the lumen of tubules in mutant testis
|
