All Phenotypes Lamc1<tm1Strl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lamc1^tm1Strl/Lamc1^tm1Strl	involves: 129P2/OlaHsd * C57BL/6	MGI:2683483
ht2	Lamc1^tm1Strl/Lamc1^tm1.2Strl	either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	MGI:5504483
cn3	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Camk2a-cre)2Szi/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2683484
cn4	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:2683489

Allelic Composition	Lamc1^tm1Strl/Lamc1^tm1Strl
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1^tm1Strl mutation (1 available); any Lamc1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:86714 )

Allelic Composition	Lamc1^tm1Strl/Lamc1^tm1.2Strl
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1^tm1.2Strl mutation (0 available); any Lamc1 mutation (143 available)
Lamc1^tm1Strl mutation (1 available); any Lamc1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal quadriceps morphology ( J:199683 )

• with scattered small myotubues and central nuclei in the absence of obvious endomysial fibrosis but an increase in interstitial collagen fibrils

decreased skeletal muscle fiber diameter ( J:199683 )

centrally nucleated skeletal muscle fibers ( J:199683 )

• in the quadriceps

decreased skeletal muscle mass ( J:199683 )

• in the lower back and hindlimbs

skeletal muscle fiber atrophy ( J:199683 )

• smaller muscle diameter

nervous system

increased Schwann cell number ( J:199683 )

• 7-fold increase in Schwann cells that do not myelinate

demyelination ( J:199683 )

• areas of amyelination with 2-fold reduction in myelinated axons and near-complete absence of enveloped axons and naked axons

behavior/neurological

limb grasping ( J:199683 )

• slightly tremulous and retracted inward limbs when suspended by tail

paraparesis ( J:199683 )

• with difficulty in ambulation

cellular

abnormal basement membrane morphology ( J:199683 )

• 2-fold decrease of Schwann cell lamellipodial processesed basement membrane

limbs/digits/tail

abnormal quadriceps morphology ( J:199683 )

• with scattered small myotubues and central nuclei in the absence of obvious endomysial fibrosis but an increase in interstitial collagen fibrils

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:86714 )

• tremor that persists even under deep anesthesia

forelimb paralysis ( J:86714 )

• in the most severely affected mutants, motor defects are also seen in the front legs

hindlimb paralysis ( J:86714 )

• mutants appear normal for 2-3 weeks after birth but by 4 weeks, begin to show hind leg weakness that leads to completely paralyzed hind legs by 3 months of age

nervous system

abnormal Schwann cell morphology ( J:86714 )

• Schwann cells are present in nerves but do not differentiate; they have a discontinuous basal lamina, are arrested at the premyelination stage and do not form myelin

abnormal axon radial sorting ( J:86714 )

• defect in axon sorting and myelination of the dorsal root of the spinal cord

• sciatic nerves are only partially myelinated and have large bundles of naked, unsorted axons

abnormal dorsal spinal root morphology ( J:86714 )

• defect in axon sorting and myelination of the dorsal root of the spinal cord

abnormal sciatic nerve morphology ( J:86714 )

• sciatic nerves are only partially myelinated and have large bundles of naked, unsorted axons

abnormal ventral spinal root morphology ( J:86714 )

• defect in axon sorting and myelination of the dorsal root of the spinal cord; more severe than in dorsal root

abnormal myelination ( J:86714 )

• Schwann cells in nerves have normal proliferation and apoptosis during development however, they fail to sort and myelinate axons

abnormal peripheral nervous system regeneration ( J:86714 )

• regeneration of the sciatic nerve after injury is impaired

homeostasis/metabolism

abnormal response to injury ( J:86714 )

• regeneration of the sciatic nerve after injury is impaired

muscle

muscular atrophy ( J:86714 )

• muscular atrophy is seen by 3 months of age

Allelic Composition	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1^tm1Strl mutation (1 available); any Lamc1 mutation (143 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon radial sorting ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

abnormal sciatic nerve morphology ( J:86714 )

• mutant sciatic nerves are undermyelinated even though many Schwann cells are present

abnormal myelination ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

behavior/neurological

tremors ( J:86714 )

forelimb paralysis ( J:86714 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24