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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gabrr1tm1Llu
targeted mutation 1, Luo Lu
MGI:2683490
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gabrr1tm1Llu/Gabrr1tm1Llu involves: 129S4/SvJae * C57BL/6 MGI:2683491


Genotype
MGI:2683491
hm1
Allelic
Composition
Gabrr1tm1Llu/Gabrr1tm1Llu
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrr1tm1Llu mutation (1 available); any Gabrr1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increase in mechanical pain sensitivity relative to wild-type, as shown by a decrease in the threshold for mechanical pain production in the von Frey filament test

nervous system
• altered GABA-mediated spinal cord response; the effect of GABA on depolarization potentials is less effective than in wild-type

taste/olfaction
• mutants are more sensitive to the smell of citral odorant than wild-type mice, moving out of the chamber containing the odorant significantly faster than controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory