About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Icostm1Flv
targeted mutation 1, Richard A Flavell
MGI:2683635
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Icostm1Flv/Icostm1Flv involves: 129/Sv * C57BL/6 MGI:2683647
hm2
 		Icostm1Flv/Icostm1Flv involves: 129S1/Sv MGI:3851525
hm3
 		Icostm1Flv/Icostm1Flv NOD.129S1-Icostm1Flv MGI:3844531
ht4
 		Icostm1Flv/Icos+ NOD.129S1-Icostm1Flv MGI:3844532
cx5
 		Cd86tm2Shr/Cd86tm2Shr
Icostm1Flv/Icostm1Flv 		involves: 129S1/Sv * 129S4/SvJaeSor MGI:3851527
cx6
 		Icostm1Flv/Icostm1Flv
Tg(TcraTcrb)425Cbn/0 		involves: 129S1/Sv * C57BL/6 MGI:3851526
cx7
 		Icostm1Flv/Icostm1Flv
Tg(Cd4-Maf)6666Glm/0 		involves: 129S1/Sv * C57BL/6 MGI:3851534
cx8
 		Icostm1Flv/Icostm1Flv
Rc3h1san/Rc3h1+ 		involves: 129S1/Sv * C57BL/6 * C57BL/6JSfdAnu MGI:5445418


Genotype
MGI:2683647
hm1
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:87123 )
N
• T lymphocyte development normal in the thymus
decreased IgE level ( J:87123 )
• production of IgE reduced
decreased IgG1 level ( J:87123 )
• reduction of IgG1 levels
abnormal T-helper 2 physiology ( J:87123 )
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted
abnormal interferon level ( J:87123 )
• Ifn-gamma levels were normal to slightly increased
abnormal interleukin level ( J:87123 )
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced
small lymph nodes ( J:87123 )
• lymph nodes were small in immunized mice
• about 1/2 as many cells/node as in wild-type mice
increased susceptibility to experimental autoimmune encephalomyelitis ( J:87123 )
• greater succeptibility to experimental autoimmune encephalitis

homeostasis/metabolism
abnormal interferon level ( J:87123 )
• Ifn-gamma levels were normal to slightly increased
abnormal interleukin level ( J:87123 )
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced

hematopoietic system
decreased IgE level ( J:87123 )
• production of IgE reduced
decreased IgG1 level ( J:87123 )
• reduction of IgG1 levels
abnormal T-helper 2 physiology ( J:87123 )
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
common variable immunodeficiency DOID:12177 OMIM:PS607594
 J:87123




Genotype
MGI:3851525
hm2
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:112600 )
• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce less IL-4, IL-17a and interferon gamma than wild-type in response to KLH restimulation




Genotype
MGI:3844531
hm3
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Genetic
Background		 NOD.129S1-Icostm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131529 )
N
• development of lymphocytes is normal
insulitis ( J:131529 )
• only a few mice develop marginal levels of inflammation of the islets
decreased T cell number ( J:131529 )
• the number of CD25+ and FoxP3+ CD4 T cells in the periphery and pancreatic draining lymph nodes is decreased 30% compared to in heterozygotes
• the frequency of IFN-gamma+ T cells is decreased compared to in heterozygous mice
decreased interferon-gamma secretion ( J:131529 )
• the frequency of IFN-gamma+ T cells is decreased compared to in heterozygous mice
decreased susceptibility to autoimmune diabetes ( J:131529 )
• after 60 weeks, no mice develop diabetes compared with 65% of heterozygotes and 75% in wild-type NOD mice
decreased autoantibody level ( J:131529 )
• anti-GAD65 and anti-insulin antibodies are decreased 3- to 5-fold compared to in heterozygotes
decreased anti-insulin autoantibody level ( J:131529 )
• decreased 3- to 5-fold compared to in heterozygotes

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:131529 )
N
• mice exhibit normal numbers of pancreatic islets
insulitis ( J:131529 )
• only a few mice develop marginal levels of inflammation of the islets

hematopoietic system
decreased T cell number ( J:131529 )
• the number of CD25+ and FoxP3+ CD4 T cells in the periphery and pancreatic draining lymph nodes is decreased 30% compared to in heterozygotes
• the frequency of IFN-gamma+ T cells is decreased compared to in heterozygous mice




Genotype
MGI:3844532
ht4
Allelic
Composition		 Icostm1Flv/Icos+
Genetic
Background		 NOD.129S1-Icostm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:131529 )
• severe

immune system
insulitis ( J:131529 )
• severe




Genotype
MGI:3851527
cx5
Allelic
Composition		 Cd86tm2Shr/Cd86tm2Shr
Icostm1Flv/Icostm1Flv
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd86tm2Shr mutation (3 available); any Cd86 mutation (39 available)
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine level ( J:112600 )
• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce no IL-4, IL-17a or interferon gamma in response to KLH restimulation

homeostasis/metabolism
abnormal cytokine level ( J:112600 )
• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce no IL-4, IL-17a or interferon gamma in response to KLH restimulation




Genotype
MGI:3851526
cx6
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:112600 )
• naive CD4 T cells cultured with OVA peptide-loaded wild-type splenic antigen presenting cells (APCs) and restimulated with anti-CD3 and secrete less IL-4 and IL-17a and more interferon gamma (Ifng) than stimulated wild-type CD4 T cells
• CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 do not produce IL-4, IL-17a or Ifng




Genotype
MGI:3851534
cx7
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Tg(Cd4-Maf)6666Glm/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
Tg(Cd4-Maf)6666Glm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:112600 )
• T cells activated for 4 days with anti-CD3 and wild-type antigen presenting cells produce more IL-4 than controls but production of IL-17a and interferon gamma is much lower




Genotype
MGI:5445418
cx8
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Rc3h1san/Rc3h1+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (3 available); any Icos mutation (37 available)
Rc3h1san mutation (7 available); any Rc3h1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:189087 )
• 5 of 25 double mutants develop T cell lymphoma
decreased lymphoma incidence ( J:189087 )
• tumor incidence (about 20%) is reduced compared to Rc3h1 heterozygotes (more than 50%)

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:189087 )
• 5 of 25 double mutants develop T cell lymphoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:189087 )
• 5 of 25 double mutants develop T cell lymphoma

immune system
increased T cell derived lymphoma incidence ( J:189087 )
• 5 of 25 double mutants develop T cell lymphoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory