Phenotypes associated with this allele

• Allele Symbol: Icos^tm1Shr
• Allele Name: targeted mutation 1, Arlene H Sharpe
• Allele ID: MGI:2683665
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icos^tm1Shr/Icos^tm1Shr	Not Specified	MGI:2683669

Genotype
MGI:2683669

hm1

• Allelic Composition: Icos^tm1Shr/Icos^tm1Shr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:87124 )

abnormal spleen germinal center morphology ( J:87124 )

• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number

• organization of germinal centers remained normal

abnormal immunoglobulin level ( J:87124 )

• IgM response remained normal

decreased IgE level ( J:87124 )

• production of IgE extremely low or absent

increased IgG3 level ( J:87124 )

• IgG3 levels were slightly elevated

decreased IgG level ( J:87124 )

• after immunization with alum or incomplete Freund's adjuvant

decreased IgG1 level ( J:87124 )

• reduction of IgG1 levels to under 2% of normal

decreased IgG2a level ( J:87124 )

• reduction of IgG2a level to around 6% of normal

abnormal CD4-positive, alpha-beta T cell physiology ( J:87124 )

• proliferation reduced

immune system

abnormal T cell differentiation ( J:87124 )

abnormal spleen germinal center morphology ( J:87124 )

• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number

• organization of germinal centers remained normal

abnormal immunoglobulin level ( J:87124 )

• IgM response remained normal

decreased IgE level ( J:87124 )

• production of IgE extremely low or absent

increased IgG3 level ( J:87124 )

• IgG3 levels were slightly elevated

decreased IgG level ( J:87124 )

• after immunization with alum or incomplete Freund's adjuvant

decreased IgG1 level ( J:87124 )

• reduction of IgG1 levels to under 2% of normal

decreased IgG2a level ( J:87124 )

• reduction of IgG2a level to around 6% of normal

abnormal CD4-positive, alpha-beta T cell physiology ( J:87124 )

• proliferation reduced

abnormal interleukin level ( J:87124 )

• Il-4 levels not detectable

• Il-10 levels not detectable

homeostasis/metabolism

abnormal interleukin level ( J:87124 )

• Il-10 levels not detectable

• Il-4 levels not detectable

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
common variable immunodeficiency		DOID:12177	OMIM:PS607594	J:87124