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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mogtm1Reid
targeted mutation 1, Hugh H Reid
MGI:2683672
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mogtm1Reid/Mogtm1Reid 129/Sv-Mogtm1Reid MGI:2683695
hm2
 		Mogtm1Reid/Mogtm1Reid B6.129S1/Sv-Mogtm1Reid MGI:2683694


Genotype
MGI:2683695
hm1
Allelic
Composition		 Mogtm1Reid/Mogtm1Reid
Genetic
Background		 129/Sv-Mogtm1Reid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1Reid mutation (0 available); any Mog mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:86663 )
• mutants exhibit higher proliferation in response to stimulation with the priming antigen MOG, but show normal responses to KLH
abnormal T-helper 1 physiology ( J:86663 )
• splenocytes from mutants stimulated with a MOG(35-55) peptide mount a stronger Th1 response than wild-type mice
abnormal cytokine secretion ( J:86663 )
• mutants immunized with a MOG(35-55) peptide to induce EAE exhibit an increase in GM-CSF production from spleen cells
increased interleukin-2 secretion ( J:86663 )
• mutants immunized with a MOG(35-55) peptide to induce EAE exhibit an increase in IL-2 production from spleen cells
increased interleukin-6 secretion ( J:86663 )
• mutants immunized with a MOG(35-55) peptide to induce EAE exhibit an increase in IL-6 production from spleen cells
increased susceptibility to experimental autoimmune encephalomyelitis ( J:86663 )
• adaptive transfer of MOG(35-55) specific T cells from mutants into wild-type recipients results in the development of a more severe experimental autoimmune encephalomyelitis (EAE) relative to wild-type
• mice have greater encephalogenic potential than wild-type mice

hematopoietic system
increased T cell proliferation ( J:86663 )
• mutants exhibit higher proliferation in response to stimulation with the priming antigen MOG, but show normal responses to KLH
abnormal T-helper 1 physiology ( J:86663 )
• splenocytes from mutants stimulated with a MOG(35-55) peptide mount a stronger Th1 response than wild-type mice

cellular
increased T cell proliferation ( J:86663 )
• mutants exhibit higher proliferation in response to stimulation with the priming antigen MOG, but show normal responses to KLH




Genotype
MGI:2683694
hm2
Allelic
Composition		 Mogtm1Reid/Mogtm1Reid
Genetic
Background		 B6.129S1/Sv-Mogtm1Reid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1Reid mutation (0 available); any Mog mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:86663 )
• adaptive transfer of MOG(35-55) specific T cells from mutants into wild-type recipients results in the development of a more severe experimental autoimmune encephalomyelitis (EAE) relative to wild-type
• mice have greater encephalogenic potential than wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory