Phenotypes associated with this allele

• Allele Symbol: Dppa3^tm1Masu
• Allele Name: targeted mutation 1, M Azim Surani
• Allele ID: MGI:2683709
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dppa3^tm1Masu/Dppa3^tm1Masu	involves: 129S/SvEv	MGI:2683730
ht2	Dppa3^tm1Masu/Dppa3^+	involves: 129S/SvEv	MGI:2683731

Genotype
MGI:2683730

hm1

• Allelic Composition: Dppa3^tm1Masu/Dppa3^tm1Masu
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

female infertility ( J:86824 )

♀ • germ cell development is normal

♀ • preimplantation failure of development

♀ • normal numbers of zygotes, then a progressive loss through E3.5

♀ • only 8% reach blastocyst stage

♀ • due to loss of maternal protein by morula stage

♀ • embryonic protein product in heterozygous embryos is insufficient to rescue development

cellular

maternal effect ( J:86824 )

Genotype
MGI:2683731

ht2

• Allelic Composition: Dppa3^tm1Masu/Dppa3⁺
• Genetic Background: involves: 129S/SvEv

reproductive system

reproductive system phenotype ( J:86824 )

N • heterozygous mothers produce offspring in normal Mendelian ratios

N • persistence of maternal protein in embryos up to the early morula stage is sufficient to permit implantation