Phenotypes associated with this allele

• Allele Symbol: Becn1^tm1Htz
• Allele Name: targeted mutation 1, Nathaniel Heintz
• Allele ID: MGI:2683833
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Becn1^tm1Htz/Becn1^tm1Htz	involves: 129P2/OlaHsd	MGI:2683841
ht2	Becn1^tm1Htz/Becn1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2683842

Genotype
MGI:2683841

hm1

• Allelic Composition: Becn1^tm1Htz/Becn1^tm1Htz
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired autophagy ( J:86982 )

• embryonic stem cells are defective in autophagy in response to starvation but undergo normal apoptosis

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:86982 )

• mutants die between E7.5 and E8.5

embryo

increased embryonic tissue cell apoptosis ( J:86982 )

• widespread cell death in E7.5 embryos as indicated by acridine orange staining

embryonic growth arrest ( J:86982 )

• observed by E7.5

decreased embryo size ( J:86982 )

• small embryo size at E7.5

abnormal amnion morphology ( J:86982 )

• no evidence of proamniotic canal closure is seen at E7.5

absent amniotic folds ( J:86982 )

• amniotic folds fail to develop

growth/size/body

decreased embryo size ( J:86982 )

• small embryo size at E7.5

cellular

impaired autophagy ( J:86982 )

• embryonic stem cells are defective in autophagy in response to starvation but undergo normal apoptosis

increased embryonic tissue cell apoptosis ( J:86982 )

• widespread cell death in E7.5 embryos as indicated by acridine orange staining

Genotype
MGI:2683842

ht2

• Allelic Composition: Becn1^tm1Htz/Becn1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Increased cancer rate in Becn1^tm1Htz/Becn1⁺ mice

neoplasm

increased tumor incidence ( J:86982 )

• 59% of mutants develop tumors compared to 14% of wild-type mice between 18 and 22 months of age; tumors are larger and of different types than in wild-type

• however, do not observe loss of heterozygosity in tumors

increased hepatocellular carcinoma incidence ( J:86982 )

increased B cell derived lymphoma incidence ( J:86982 )

increased lung adenocarcinoma incidence ( J:86982 )

respiratory system

increased lung adenocarcinoma incidence ( J:86982 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:86982 )