Phenotypes associated with this allele

• Allele Symbol: Sema7a^tm1Alk
• Allele Name: targeted mutation 1, Alex L Kolodkin
• Allele ID: MGI:2683867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema7a^tm1Alk/Sema7a^tm1Alk	involves: 129S6/SvEvTac * C57BL/6	MGI:2683896

Genotype
MGI:2683896

hm1

• Allelic Composition: Sema7a^tm1Alk/Sema7a^tm1Alk
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:87191 )

• retrograde DiI axon tracing in coronal brain sections indicates that the overall LOT projection is either significantly reduced in size or entirely absent at the most caudal levels, suggesting that most OB axons fail to project into the most caudal parts of the olfactory cortex by E16

• in vivo, branching of the LOT appears to be reduced probably due to an overall outgrowth impairment; however, no effect on OB axon branching is observed in vitro or in situ

abnormal olfactory tract morphology ( J:87191 )

• at E16, homozygotes display impaired lateral olfactory tract (LOT) outgrowth relative to wild-type and heterozygous control littermates

• an abnormally narrow LOT morphology is observed in E16 whole-mount mutant brains

• most olfactory bulb (OB) axons fail to project into the most caudal parts of the olfactory cortex by E16, as shown by retrograde DiI axon tracing in coronal brain sections

• however, both OB cytoarchitecture and mitral/tufted cell numbers are normal, and tract positioning in the telencephalon remains unaffected

cellular

abnormal axon extension ( J:87191 )

• retrograde DiI axon tracing in coronal brain sections indicates that the overall LOT projection is either significantly reduced in size or entirely absent at the most caudal levels, suggesting that most OB axons fail to project into the most caudal parts of the olfactory cortex by E16

• in vivo, branching of the LOT appears to be reduced probably due to an overall outgrowth impairment; however, no effect on OB axon branching is observed in vitro or in situ