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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxnc1tm1Alk
targeted mutation 1, Alex L Kolodkin
MGI:2683882
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plxnc1tm1Alk/Plxnc1tm1Alk B6.129-Plxnc1tm1Alk MGI:2683893
hm2
 		Plxnc1tm1Alk/Plxnc1tm1Alk involves: 129 MGI:5007638
hm3
 		Plxnc1tm1Alk/Plxnc1tm1Alk involves: 129/Sv * C57BL/6 MGI:3709868


Genotype
MGI:2683893
hm1
Allelic
Composition		 Plxnc1tm1Alk/Plxnc1tm1Alk
Genetic
Background		 B6.129-Plxnc1tm1Alk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnc1tm1Alk mutation (0 available); any Plxnc1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:87191 )
• homozygotes are born at the expected Mendelian frequency, are overtly normal, and display normal development of the lateral olfactory tract




Genotype
MGI:5007638
hm2
Allelic
Composition		 Plxnc1tm1Alk/Plxnc1tm1Alk
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnc1tm1Alk mutation (0 available); any Plxnc1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:172268 )
N
• mice exhibit normal retinal stratification




Genotype
MGI:3709868
hm3
Allelic
Composition		 Plxnc1tm1Alk/Plxnc1tm1Alk
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnc1tm1Alk mutation (0 available); any Plxnc1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:120909 )
• these neurons are distributed less coherently in the PVN relative to heterozygous controls
• more Sim1-positive neurons are in the intermediate position in mutants
• mutant OT and VP neurons are scattered along the medial-lateral axis
• in adult mutants, distribution of the midway-scattered VP and OT neurons in the PVN is less organized than in heterozygous controls
abnormal neuron morphology ( J:120909 )
• at P2, there is an ~3-fold increase in oxytocin-expressing (OT) neurons and an ~5-fold increase in vasopressin-expressing (VP) neurons in region between the paraventricular nucleus (PVN) and supraoptic nucleus (SON)

cellular
abnormal neuronal migration ( J:120909 )
• these neurons are distributed less coherently in the PVN relative to heterozygous controls
• more Sim1-positive neurons are in the intermediate position in mutants
• mutant OT and VP neurons are scattered along the medial-lateral axis
• in adult mutants, distribution of the midway-scattered VP and OT neurons in the PVN is less organized than in heterozygous controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory