About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itpkctm1Ssch
targeted mutation 1, Stephane Schurmans
MGI:2683901
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itpkctm1Ssch/Itpkctm1Ssch involves: 129S1/Sv * 129X1/SvJ MGI:2683923
cx2
Itpkbtm1Ssch/Itpkbtm1Ssch
Itpkctm1Ssch/Itpkctm1Ssch
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2683926


Genotype
MGI:2683923
hm1
Allelic
Composition
Itpkctm1Ssch/Itpkctm1Ssch
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpkctm1Ssch mutation (1 available); any Itpkc mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes exhibit normal thymocyte development




Genotype
MGI:2683926
cx2
Allelic
Composition
Itpkbtm1Ssch/Itpkbtm1Ssch
Itpkctm1Ssch/Itpkctm1Ssch
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpkbtm1Ssch mutation (0 available); any Itpkb mutation (40 available)
Itpkctm1Ssch mutation (1 available); any Itpkc mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after stimulation of thymocytes with concanavalin A or anti-CD3 antibody, double homozygotes display significantly reduced concentrations of Ins(1,3,4,5)P4 relative to similarly-treated controls
• however, no defects in calcium mobilization are observed following stimulation of double mutant thymocytes with ionomycin or CD3 mAb treatment, similar to single Itpkbtm1Ssch homozygotes
• double homozygotes display a developmental block between the double-positive and mature single-positive thymocyte stage, similar to that observed in single Itpkbtm1Ssch homozygotes
• double homozygotes display near absence of mature CD4+ T cells in lymph nodes and spleen, similar to that observed in single Itpkbtm1Ssch homozygotes
• double homozygotes display near absence of mature CD8+ T cells in lymph nodes and spleen, similar to that observed in single Itpkbtm1Ssch homozygotes

hematopoietic system
• after stimulation of thymocytes with concanavalin A or anti-CD3 antibody, double homozygotes display significantly reduced concentrations of Ins(1,3,4,5)P4 relative to similarly-treated controls
• however, no defects in calcium mobilization are observed following stimulation of double mutant thymocytes with ionomycin or CD3 mAb treatment, similar to single Itpkbtm1Ssch homozygotes
• double homozygotes display a developmental block between the double-positive and mature single-positive thymocyte stage, similar to that observed in single Itpkbtm1Ssch homozygotes
• double homozygotes display near absence of mature CD4+ T cells in lymph nodes and spleen, similar to that observed in single Itpkbtm1Ssch homozygotes
• double homozygotes display near absence of mature CD8+ T cells in lymph nodes and spleen, similar to that observed in single Itpkbtm1Ssch homozygotes

endocrine/exocrine glands
• after stimulation of thymocytes with concanavalin A or anti-CD3 antibody, double homozygotes display significantly reduced concentrations of Ins(1,3,4,5)P4 relative to similarly-treated controls
• however, no defects in calcium mobilization are observed following stimulation of double mutant thymocytes with ionomycin or CD3 mAb treatment, similar to single Itpkbtm1Ssch homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/05/2024
MGI 6.24
The Jackson Laboratory